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Cell adhesion molecule cadherin-6 function in zebrafish cranial and lateral line ganglia development

机译:细胞粘附分子钙黏着蛋白6在斑马鱼颅骨和侧线神经节发育中的功能

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摘要

Cadherins regulate the vertebrate nervous system development. We previously showed that cadherin-6 message (cdh6) was strongly expressed in the majority of the embryonic zebrafish cranial and lateral line ganglia during their development. Here, we present evidence that cdh6 has specific functions during cranial and lateral line ganglia and nerve development. We analyzed the consequences of cdh6 loss-of-function on cranial ganglion and nerve differentiation in zebrafish embryos. Embryos injected with zebrafish cdh6 specific antisense morpholino oligonucleotides (MOs, which suppress gene expression during development; cdh6 morphant embryos) displayed a specific phenotype, including (i) altered shape and reduced development of a subset of the cranial and lateral line ganglia (e.g., the statoacoustic ganglion and vagal ganglion) and (ii) cranial nerves were abnormally formed. These data illustrate an important role for cdh6 in the formation of cranial ganglia and their nerves.
机译:钙黏着蛋白调节脊椎动物的神经系统发育。我们以前显示钙粘蛋白6信息(cdh6)在其发育过程中的大多数胚胎斑马鱼颅和侧线神经节中强烈表达。在这里,我们提供证据证明cdh6在颅和侧线神经节和神经发育过程中具有特定功能。我们分析了cdh6功能丧失对斑马鱼胚胎中颅神经节和神经分化的影响。斑马鱼cdh6特异性反义吗啉代寡核苷酸(MOs,在发育过程中抑制基因表达; cdh6 morphant胚胎)注射的胚表现出特定表型,包括(i)形状改变和一部分颅和侧线神经节的发育减少(例如,静听神经节和迷走神经节)和(ii)颅神经异常形成。这些数据说明了cdh6在颅神经节及其神经形成中的重要作用。

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