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Design, Synthesis and Testing of Novel Classes of Inhibitors Against Metallo-β-lactamases: Towards Drug Leads to Combat Antibiotic Resistance

机译：新型金属β-内酰胺酶抑制剂的设计，合成和测试：迈向对抗抗生素耐药性的药物

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Yusof Yusralina;
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年度 2015
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正文语种 eng
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1. X-ray crystallographic analysis of IMP-1 metallo-β-lactamase complexed with a 3-aminophthalic acid derivative, structure-based drug design, and synthesis of 3,6-disubstituted phthalic acid derivative inhibitors [J] . HiraiwaY., SaitoJ., WatanabeT., Bioorganic and Medicinal Chemistry Letters . 2014,第20期

机译：与3-氨基邻苯二甲酸衍生物复合的IMP-1金属β-内酰胺酶的X射线晶体学分析，基于结构的药物设计以及3,6-二取代邻苯二甲酸衍生物抑制剂的合成
2. Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance [J] . Parai M.K., Huggins D.J., Cao H., Journal of Medicinal Chemistry . 2012,第14期

机译：新型HIV-1蛋白酶抑制剂抗药性的设计，合成以及生物学和结构评估
3. Design, synthesis, protein-ligand X-ray structure, and biological evaluation of a series of novel macrocyclic human immunodeficiency virus-1 protease inhibitors to combat drug resistance [J] . Ghosh A.K., Kulkarni S., Anderson D.D., Journal of Medicinal Chemistry . 2009,第23期

机译：设计，合成，蛋白质配体X射线结构和生物学评估一系列新型大环人类免疫缺陷病毒1蛋白酶抑制剂以抗药性
4. Study of Drug Resistance in Clinical Isolates of Enterococci with special reference to high level aminoglycoside resistance, beta lactamase production and lateral transfer of drug resistance [C] . M.G. Karmarkar, Edwin S. Gershom, Santosh Kaul, Lancefield International Symposium on Streptococci and Streptococcal Diseases . 2006

机译：肠球菌临床分离株的耐药性研究，特别是高水平氨基糖苷抵抗，β内酰胺酶生产和耐药性横向转移
5. Mechanism Elucidation and Inhibitor Discovery against Serine and Metallo-β-Lactamases Involved in Bacterial Antibiotic Resistance [D] . Pemberton, Orville A. 2017

机译：针对丝氨酸和金属-β-内酰胺酶的机制阐明和抑制剂发现，所述细菌抗生素抗性
6. Potential inhibitors designed against NDM-1 type metallo-β-lactamases: an attempt to enhance efficacies of antibiotics against multi-drug-resistant bacteria [O] . Asad U. Khan, Abid Ali, Danishuddin, -1

机译：设计针对NDM-1型金属β-内酰胺酶的潜在抑制剂：尝试增强抗生素对耐多药细菌的功效
7. Potential inhibitors designed against NDM-1 type metallo-β-lactamases: an attempt to enhance efficacies of antibiotics against multi-drug-resistant bacteria [O] . Asad U. Khan, Abid Ali, Gaurava Srivastava, 2017

机译：针对NDM-1型金属-β-内酰胺酶设计的潜在抑制剂：试图增强抗生素对多种耐药细菌的疗效

Design, Synthesis and Testing of Novel Classes of Inhibitors Against Metallo-β-lactamases: Towards Drug Leads to Combat Antibiotic Resistance

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