Imbalance of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 is Associated with Pulmonary Emphysema in Klotho Mice

摘要

Klotho mice, which exhibit multiple phenotypes resembling human aging, developpulmonary emphysema. In this study, to clarify the mechanism of their emphysematouschange through development, we evaluated the expression of matrix metalloproteinase(MMP)-2, 9