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All translation elongation factors and the e, f, and h subunits of translation initiation factor 3 are encoded by 5'-terminal oligopyrimidine (TOP) mRNAs

机译:所有翻译延伸因子和翻译起始因子3的e,f和h亚基均由5'-末端寡嘧啶(TOP)mRNA编码

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摘要

Terminal oligopyrimidine (TOP) mRNAs (encoded by the TOP genes) are identified by a sequence of 6-12 pyrimidines at the 5' end and by a growth-associated translational regulation. All vertebrate genes for the 80 ribosomal proteins and some other genes involved, directly or indirectly, in translation, are TOP genes. Among the numerous translation factors, only eEF1A and eEF2 are known to be encoded by TOP genes, most of the others having not been analyzed. Here, we report a systematic analysis of the human genes for translation factors. Our results show that: (1) all five elongation factors are encoded by TOP genes; and (2) among the initiation and termination factors analyzed, only eIF3e, eIF3f, and eIF3h exhibit the characteristics of TOP genes. Interestingly, these three polypeptides have been recently shown to constitute a specific subgroup among eIF3 subunits. In fact, eIF3e, eIF3f, and eIF3h are the part of the functional core of eIF3 that is not conserved in Saccharomyces cerevisiae. It has been hypothesized that they are regulatory subunits, and the fact that they are encoded by TOP genes may be relevant for their function.
机译:末端低聚嘧啶(TOP)mRNA(由TOP基因编码)通过5'端的6-12个嘧啶序列和与生长相关的翻译调控进行鉴定。 80种核糖体蛋白的所有脊椎动物基因以及直接或间接参与翻译的其他一些基因都是TOP基因。在众多翻译因子中,只有eEF1A和eEF2已知由TOP基因编码,其他大多数未进行分析。在这里,我们报告了人类基因翻译因子的系统分析。我们的结果表明:(1)所有五个延伸因子均由TOP基因编码; (2)在分析的起始和终止因子中,只有eIF3e,eIF3f和eIF3h表现出TOP基因的特征。有趣的是,最近已显示这三种多肽构成eIF3亚基中的特定亚组。实际上,eIF3e,eIF3f和eIF3h是eIF3功能核心的一部分,在酿酒酵母中不保守。已经假设它们是调节亚基,并且它们由TOP基因编码的事实可能与其功能有关。

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