Phosphonated Carbocyclic 2'-Oxa-3'-azanucleosides as New Antiretroviral Agents

摘要

Phosphonated carbocyclic 2¢-oxa-3¢-azanucleosides have been synthesized and tested for their antiretroviraludactivity. The obtained results have shown that some of the compounds were as powerful as azydothymidineudin inhibiting the reverse transcriptase activity of the human retrovirus T-cell leukemia/lymphotropic virusudtype 1 and in protecting human peripheral blood mononuclear cells against human retrovirus T-cell leukemia/udlymphotropic virus type 1 transmission in vitro. These data indicate that phosphonated carbocyclic 2¢-oxa-ud3¢-azanucleosides possess the necessary requirements to efficiently counteract infections caused by humanudretroviruses.