Re-engineering Electrochemical Biosensors To Narrow or Extend Their Useful Dynamic Range

摘要

By combining DNA probes having different target affinities, but with similar specificity on the same electrode, an extended dynamic response of a biosensor spanning three orders of magnitude in target concentration was obtained. By using a different strategy, the useful dynamic range of an electrochemical DNA sensor was narrowed to only an 8-fold range of target concentrations.