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Measurement of homonuclear three-bond J(HNHa) coupling constants in unlabeled peptides complexed with labeled proteins: Application to a decapeptide inhibitor bound to the proteinase domain of the NS3 protein of hepatits C virus (HCV)

机译：与标记蛋白复合的未标记肽中同核三键J（HNHa）偶联常数的测量：应用于结合C型肝炎病毒（HCV）NS3蛋白蛋白酶结构域的十肽抑制剂

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A new isotope-filtered experiment has been designed to measure homonuclear three-bond J(H(N)Halpha) coupling constants of unlabeled peptides complexed with labeled proteins. The new experiment is based on the 3D HNHA pulse scheme, and belongs to the 'quantitative J-correlation' type. It has been applied to a decapeptide inhibitor bound to the proteinase domain of the NS3 protein of human hepatitis C virus (HCV).

机译：设计了一个新的同位素过滤实验，以测量与标记蛋白复合的未标记肽的同核三键J（H（N）Halpha）偶联常数。新的实验基于3D HNHA脉冲方案，属于“定量J相关”类型。它已应用于结合人丙型肝炎病毒（HCV）NS3蛋白的蛋白酶结构域的十肽抑制剂。

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Cicero DO; Barbato G; Koch U; Ingallinella P; Bianchi E; Sambucini S; Neddermann P; De Francesco R; Pessi A; Bazzo R;
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年度 2001
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正文语种 eng
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1. Measurement of homonuclear three-bond J((HH alpha)-H-N) coupling constants in unlabeled peptides complexed with labeled proteins: Application to a decapeptide inhibitor bound to the proteinase domain of the NS3 protein of hepatitis C virus (HCV) [J] . Cicero DO., Koch U., Ingallinella P., Journal of Biomolecular NMR . 2001,第1期

机译：与标记蛋白复合的未标记肽中同核三键J（（HHα）-H-N）偶联常数的测量：应用于结合丙型肝炎病毒（HCV）NS3蛋白蛋白酶结构域的十肽抑制剂
2. Structural characterization of the interactions of optimized product inhibitors with the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein by NMR and modelling studies. [J] . Cicero DO, Barbato G, Koch U, Journal of Molecular Biology . 1999,第2期

机译：通过NMR和建模研究，优化产物抑制剂与丙型肝炎病毒（HCV）NS3蛋白N末端蛋白酶结构域的相互作用的结构表征。
3. The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism. [J] . Barbato G, Cicero DO, Nardi MC, Journal of Molecular Biology . 1999,第2期

机译：丙型肝炎病毒（HCV）NS3蛋白N末端蛋白酶结构域的溶液结构为其激活和催化机制提供了新见解。
4. Peptide-based protease inhibitors of the hepatitis C virus full-length NS3 protein (protease-helices/NTPase) [C] . Anja Johansson, Eva Akerblom, Gunnar Lindeberg, European Peptide Symposium . 2002

机译：基于肽的蛋白质蛋白酶抑制剂甲型肝炎病毒全长NS3蛋白（蛋白酶 - 螺旋/ NTPAse）
5. Pseudoxazolones as hepatitis A virus 3C proteinase inhibitors and bacterially derived antimicrobial peptides. [D] . Martin, Nathaniel Isaac. 2004

机译：伪唑啉酮作为甲型肝炎病毒3C蛋白酶抑制剂和细菌衍生的抗菌肽。
6. Homonuclear decoupling for enhancing resolution and sensitivity in NOE and RDC measurements of peptides and proteins [O] . Jinfa Ying, Julien Roche, Ad Bax -1

机译：同源核解耦可增强NOE和RDC测量肽和蛋白质的分辨率和灵敏度
7. The solution structure of the N-terminal proteinase domain of the Hepatitis C Virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism [O] . Barbato G, Cicero DO, Nardi MC, 1999

机译：丙型肝炎病毒（HCV）NS3蛋白N末端蛋白酶结构域的溶液结构为其激活和催化机制提供了新见解

Measurement of homonuclear three-bond J(HNHa) coupling constants in unlabeled peptides complexed with labeled proteins: Application to a decapeptide inhibitor bound to the proteinase domain of the NS3 protein of hepatits C virus (HCV)

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