Comparison of coping, quality of life and psychosocial well-being in children and adult patients with vitiligo before and after treatment with pseudocatalase PC-KUS. A questionnaire-based investigation into social anxiety, helplessness, anxious-depressive mood, quality of life and depression before and after treatment with pseudocatalase PC-KUS depending on demographic characteristics and experiences.

摘要

Vitiligo is an idiopathic, non-contagious and often familial depigmentation disorderudaffecting both sexes equally. The mostly progressive and patchy loss of the inheritedudskin colour is not only a cosmetical problem, it has a profound impact on the patient¿sudwell-being. Stigmatisation and rejection often causes depression, self-consciousness,udsexual problems and an impaired quality of life.udTo further substantiate earlier investigations and to introduce new aspects, we utilisedudthe Dermatology Life Quality Index (DLQI), the Beck Depression Inventory (BDI) andudthe Adjustment to Chronic Skin Disorders Questionnaire (ACS) with its sub-scales onudSocial anxiety / avoidance, Helplessness and Anxious-depressive Mood in 422 patientsudand 55 healthy controls. We also included 103 children, their parents and 18 controls byudusing the Children¿s Dermatology Life Quality Index (CDLQI) and an adapted versionudof the ACS.udWe found that patients with vitiligo experience high levels of stigmatisation. They haveudan impaired quality of life and are more socially anxious / avoidant, helpless andud(anxious-) depressive compared to healthy controls. The results correlate with diseaseudseverity, avoidant behaviour / hiding of vitiligo and the belief that psychological stressudinfluences the disease. Female patients are generally more affected. Treatment withudpseudocatalase PC-KUS improves quality of life and reduces anxious-depressive mood.udChildren also suffer from stigmatisation and an impaired quality of life. Parents areudmore socially anxious and helpless compared to the control group.