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Surface Treatment of Polymeric Materials Controlling the Adhesion of Biomolecules

机译:高分子材料的表面处理可控制生物分子的粘附

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摘要

This review describes different strategies of surface elaboration for a better control of biomolecule adsorption. After a brief description of the fundamental interactions between surfaces and biomolecules, various routes of surface elaboration are presented dealing with the attachment of functional groups mostly thanks to plasma techniques, with the grafting to and from methods, and with the adsorption of surfactants. The grafting of stimuli-responsive polymers is also pointed out. Then, the discussion is focused on the protein adsorption phenomena showing how their interactions with solid surfaces are complex. The adsorption mechanism is proved to be dependent on the solid surface physicochemical properties as well as on the surface and conformation properties of the proteins. Different behaviors are also reported for complex multiple protein solutions.
机译:这篇综述描述了用于更好地控制生物分子吸附的不同表面修饰策略。在简要介绍了表面与生物分子之间的基本相互作用之后,提出了各种表面修饰途径,这些途径主要是通过等离子体技术,方法之间的接枝以及表面活性剂的吸附来处理官能团的连接。还指出了刺激反应性聚合物的接枝。然后,讨论的重点是蛋白质吸附现象,表明它们与固体表面的相互作用如何复杂。已证明吸附机理取决于固体表面的理化性质以及蛋白质的表面和构象性质。还报道了复杂的多种蛋白质溶液的不同行为。

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