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Interactions between Active-Site Serine Beta-Lactamases and So-Called Beta-Lactamase-Stable Antibiotics. Kinetic and Molecular Modelling Studies

机译:活性位点丝氨酸β-内酰胺酶和所谓的β-内酰胺酶稳定的抗生素之间的相互作用。动力学和分子建模研究

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摘要

The interactions between imipenem and four monobactams and three class A beta-lactamases have been studied in detail. Despite their reputation as being beta-lactamase-stable, some of these compounds were significantly hydrolysed by the enzymes. The results obtained with the Streptomyces albus G beta-lactamase have been analysed in the light of molecular modelling studies. The discussion is extended to include other so-called beta-lactamase-stable antibiotics to demonstrate that this appellation can often be misleading.
机译:亚胺培南与四种单bactams和三种A类β-内酰胺酶之间的相互作用已得到详细研究。尽管它们以β-内酰胺酶稳定而著称,但其中一些化合物已被酶显着水解。根据分子模型研究,分析了链霉菌白蛋白Gβ-内酰胺酶获得的结果。讨论扩大到包括其他所谓的β-内酰胺酶稳定的抗生素,以证明这种称呼经常会产生误导。

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