Decomposition of mutational context signatures using quadratic programming methods

摘要

AGL was supported in this work by a Cancer Research UK programme grant [C14303/A20406] to Simon Tavaré. AGL acknowledges the support of the University of Cambridge, Cancer Research UK and Hutchison Whampoa Limited. Whole-genome sequencing of oesophageal adenocarcinoma was part of the oesophageal International Cancer Genome Consortium (ICGC) project. The oesophageal ICGC project was funded through a programme and infrastructure grant to Rebecca Fitzgerald as part of the OCCAMS collaboration.