Avaliação da associação entre níveis de omentina sérica e doença arterial coronariana em pacientes com síndrome metabólica

摘要

Background: Visceral obesity is associated with increased risk of cardiovascular disease when compared to peripheral obesity. Omentin, an adipokine produced in the visceral adipose tissue, is related to components of metabolic syndrome (MetS) and may be related to coronary artery disease (CAD)Objective: To evaluate the association between serum levels of omentin and CAD in patients with MetS. Design and Methods: Serum levels of omentin were measured in 75 patients with MetS in a case-control study nested in a cross-sectional study. Thirty-six patients had CAD, whereas 39 patients did not have this disorder. Results: Serum levels of omentin were lower in patients with CAD than in those without the disease, 293. 03 ng/mL (± 121. 44) and 224. 56 ng/mL (± 97. 75), respectively (P = 0009). Serum levels of omentin were divided into 4 percentile groups. The highest percentile of omentin (Q4) had a lower proportion of CAD when compared to the lowest percentile (Q1). Such proportion did not change after adjusting for age, sex, HDL, type 2 diabetes, and diastolic blood pressure (OR: 0. 13, CI: 0. 02-0. 84, P = 0. 032).Conclusions: In patients with MetS, there is reduced omentin in the group with CAD, and this relationship seems to be inversely proportional to omentin levels.