Synthesis and pharmacological evaluation of sulfamide-based analogues of anandamide

摘要

Arachidonyl and linoleyl sulfamide derivatives have been synthesized and their potential cannabimi- udmetic properties evaluated in in vitro functional and binding assays. Replacement of the ethanolamide udmoiety of anandamide by –CH2NHSO2NH–R considerably reduces the CB1 receptor activity and only udsome of the compounds showed modest cannabinoid properties in binding assays. The new compounds udwere also tested as inhibitors of the FAAH enzyme but were inactive.