Radiopaque acrylic cements prepared with a new acrylic derivative of iodo-quinoline

摘要

A novel iodine-containing methacrylate, 2,5-diiodo-8-quinolyl methacrylate, has been synthesized and used in the preparation ofudacrylic radiopaque cements. The e!ect of incorporation of this monomer to the self-curing resins, on the curing parameters, swellingudbehaviour and mechanical properties was studied. The incorporation of the radiopaque compound 2,5-diiodo-8-hydroxyquinoline toudthe solid phase was also carried out for comparative experiments. A decrease in the peak temperature and an increase in the settingudtime was observed with the addition of the radiopaque monomer, however, the curing parameters did not appreciably change with theudaddition of the radiopaque compound to the solid phase. Swelling of the modi"ed cements was in the same range as that of theudradiolucent cement; however, the di!usion coe$cients calculated according to the Fick's law were higher for the iodine-containingudmaterials. The addition of 5 wt% of the iodine-containing methacrylate provided a signi"cant increase in the tensile properties withudrespect to either control radiolucent formulations or BaSOud4ud-containing formulations. Biocompatibility of the modi"ed cements wasudstudied by implantation of rods of the cements into rats and histological analysis of the surrounding tissue.