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Prenylflavonoids and prenyl/alkyl-phloroacetophenones: Synthesis and antitumour biological evaluation

机译:异戊二烯类黄酮和异戊二烯/烷基苯乙酰苯乙酮:合成和抗肿瘤生物学评估

摘要

Several prenylflavonoids have been synthesised and tested against human tumour cell lines. The prenyl unit has been geranyl or a labdane diterpene. These labdane-flavonoids have been synthesised for the first time. The antitumour activity increase with the prenylation at C-8 position. Twenty-three C and O-prenylated acylphloroglucinols have been synthesised as well. In this case the C-alkylation products have resulted, in general, more active. © 2010 Elsevier Masson SAS. All rights reserved.
机译:已经合成了几种异戊二烯类黄酮并针对人肿瘤细胞系进行了测试。异戊二烯单元是香叶基或拉丹二萜。这些拉丹烷类黄酮是首次合成。抗肿瘤活性随C-8位置的异戊二烯化而增加。还已经合成了二十三个C和O-烯丙基化的酰基葡糖醛酸。在这种情况下,C-烷基化产物通常具有更高的活性。 ©2010 Elsevier Masson SAS。版权所有。

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