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One-pot conversion of serine derivatives and amino sugars into oxazine derivatives of γ-aryl-γ-(hydroxy)amines

机译:丝氨酸衍生物和氨基糖一锅转化为γ-芳基-γ-(羟基)胺的恶嗪衍生物

摘要

A one-pot process for the transformation of relatively inexpensive serine derivatives into oxazine derivatives of γ-aryl-γ-hydroxy-α- amino acids is described. The reaction preferentially afforded 4,6-cis oxazines. The method can also be applied to the transformation of amino sugars into highly functionalized oxazines, which are precursors of chiral amines. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
机译:描述了一种一锅法,用于将相对便宜的丝氨酸衍生物转化为γ-芳基-γ-羟基-α-氨基酸的恶嗪衍生物。反应优选得到4,6-顺式恶嗪。该方法还可用于将氨基糖转化为高度官能化的恶嗪,其是手性胺的前体。版权所有©2012 WILEY-VCH Verlag GmbH&Co.KGaA,Weinheim。

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