首页> 外文OA文献 >Oral administration of beta-1,3/1,6-glucan to dogs temporally changes total and antigen-specific IgA and IgM
【2h】

Oral administration of beta-1,3/1,6-glucan to dogs temporally changes total and antigen-specific IgA and IgM

机译:对狗口服β-1,3/ 1,6-葡聚糖会暂时改变总IgA和抗原特异性IgM

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

The effect of oral administration of beta-1,3/1,6-glucans from Saccharomyces cerevisiae on humoral immunity in domestic dogs is not known. In this study, 15 beagle dogs were orally given MacroGard tablets, which contain 150 mg of this beta-glucan, daily for 4 weeks. At the end of this period, the total serum immunoglobulin A (IgA) level decreased significantly in the group treated with the glucan compared to that in the control group as well as compared to the concentrations before supplementation. In contrast, the total serum IgM level rose significantly, whereas no effect on the IgG level occurred. Similar changes were seen in Bordetella-specific IgA and IgM titers following vaccination during the supplementation period. The IgA concentration also became significantly lower in the saliva and tears of the glucan group than in the placebo group. The effects disappeared 1 week after the cessation of the supplementation. In conclusion, the results showed a temporary change in the isotype profile during glucan supplementation.
机译:口服酿酒酵母的β-1,3/ 1,6-葡聚糖对家犬体液免疫的影响尚不清楚。在这项研究中,每天给15只比格犬口服MacroGard片剂,其中含有150毫克的这种β-葡聚糖,持续4周。在此阶段结束时,与对照组相比,与补充前的浓度相比,葡聚糖治疗组的总血清免疫球蛋白A(IgA)水平显着降低。相反,总血清IgM水平显着上升,而对IgG水平无影响。在补充期间接种疫苗后,博德特氏菌特异性IgA和IgM滴度出现了类似的变化。葡聚糖组的唾液和眼泪中的IgA浓度也显着低于安慰剂组。停止补充1周后,效果消失。总之,结果表明在葡聚糖补充过程中同种型的暂时变化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号