The purpose of the study was to develop an optimized thermoreversible in situ gelling ophthalmic drug delivery system based on Pluronic F 127, containing moxifloxacin hydrochloride as a model drug. A 32 full factorial design was employed with two polymers Pluronic F 68 and Gelrite as independent variables used in combination with Pluronic F 127. Gelation temperature, gel strength, bioadhesion force, viscosity and in vitro drug release after 1 and 10 h were selected as dependent variables. Pluronic F 68 loading with Pluronic F 127 was found to have a significant effect on gelation temperature of the formulation and to be of importance for gel formation at temperatures 3336 ºC. Gelrite loading showed a positive effect on bioadhesion force and gel strength and was also found helpful in controling the release rate of the drug. The quadratic mathematical model developed is applicable to predicting formulations with desired gelation temperature, gel strength, bioadhesion force and drug release properties.
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机译：该研究的目的是开发一种基于Pluronic F 127的优化的热可逆原位胶凝眼科药物递送系统，其中含有盐酸莫西沙星作为模型药物。采用32全因子设计，将两种聚合物Pluronic F 68和Gelrite作为与Pluronic F 127结合使用的自变量。选择凝胶温度，凝胶强度，生物粘附力，粘度和1和10小时后的体外药物释放作为依变量变量。发现使用Pluronic F 127装载Pluronic F 68对制剂的胶凝温度有显着影响，并且对于在3336ºC温度下的凝胶形成具有重要意义。胶体负载对生物粘附力和凝胶强度显示出积极影响，并且还发现有助于控制药物的释放速率。开发的二次数学模型可用于预测具有所需凝胶温度，凝胶强度，生物粘附力和药物释放特性的制剂。
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