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Synthesis of bicyclo-DNA nucleosides with additional functionalization in the carbocyclic ring

机译:在碳环中合成具有附加功能的双环DNA核苷

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摘要

Two novel bicyclo nucleoside isomers carrying the base thymine in the furanose ring and an ester substituent in the carbocyclic ring were synthesized from a common bicyclic sugar precursor via a cyclopropanation/fragmentation pathway in nine steps. The relative configuration of the ester substituent in both isomers as well as the anomeric configuration in one nucleoside was determined by 1H-NMR difference NOE spectroscopy.
机译:从普通的双环糖前体经环丙烷化/片段化途径分九步合成了两个在呋喃糖环中带有碱基胸腺嘧啶和在碳环中带有酯取代基的新型双环核苷异构体。通过1H-NMR差NOE光谱法测定两种异构体中酯取代基的相对构型以及一个核苷中的异头构型。

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