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DIGOXIN I AMIODARON KOD TRAJNE FETALNE SUPRAVENTRIKULARNE TAHIKARDIJE I NEIMUNOLOŠKOG FETALNOG HIDROPSA

机译:地高辛和胺碘酮在永久性胎儿室上性心动过速和非免疫性胎儿水肿中的作用

摘要

Supraventricular tachycardia is the most common and clinically significant form of sustained fetal tachyarrhythmia in pregnancy; depending on duration and high rate variability heart failure and nonimmune hydrops may develop which are associated with a high incidence of perinatal mortality. Doppler/echo diagnosis is usually accidental during second and third trimester of pregnancy. Therapeutic goals are cardioconversion to sinus rhythm and recovery of heart failure. We present a case of fetal supraventricualr tachycardia diagnosed at 29 weeks of gestation with nonimmune hydrops. Treatment with digoxin and amiodarone was successful. The heart rate restored to sinus rhythm and nonimmune hydrops resolved within three weeks of treatment. Therapy with two drugs that act synergistically may be more efficient than monotherapy in blocking likely atrio-ventricular reentry mechanism by accessory pathway in sustained supraventricular tachycardia, thus allowing resolution of hydrops with favorable management outcome.
机译:室上性心动过速是妊娠期胎儿持续性心律失常的最常见和临床意义。取决于持续时间和高速率变异性,可能发生心力衰竭和非免疫性积水,这与围产期死亡率的高发生率有关。多普勒/回声诊断通常是在妊娠中期和中期发生的意外情况。治疗目标是心脏转复为窦律和心力衰竭。我们提出一例胎儿妊娠性心动过速在妊娠29周时被诊断为非免疫性积水。用地高辛和胺碘酮治疗成功。治疗后三周内,心率恢复到窦性心律,非免疫性积水消失。在持续性室上性心动过速中,通过协同途径,两种药物的协同作用可能比单一疗法更有效地通过辅助途径阻断可能的房室折返机制,从而可以解决积水,并取得良好的治疗效果。

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