We evaluated changes in clinical variables and microbiological profiles of periodontopathogens among 56 patients with moderate to severe CP who were randomly assigned to oral hygiene instruction (OHI; n = 28) or nonsurgical periodontal treatment (NSPT; n = 28). Periodontal variables were assessed and subgingival plaque samples were obtained from deep pockets (≥5 mm) at baseline and 3 months after treatment. Real-time polymerase chain reaction was used to quantify Actinobacillus actinomycetemcomitans, Tannerella forsythia, Porphyromonas gingivalis, and Prevotella intermedia. All clinical variables significantly improved in both groups. Improvements in gingival bleeding index (GBI), probing pocket depth (PPD), and periodontal attachment loss (PAL) were significantly greater at 3 months after treatment in the NSPT group. At baseline, the prevalences of all pathogens were high. Significant reductions in microbial count were observed for A. actinomycetemcomitans and T. forsythia (P ≤ 0.05) in the NSPT group. None of the improvements in clinical variables was associated with changes in microbiological profiles. At 3 months after treatment, NSPT was associated with significantly greater improvements in GBI, PPD, and PAL as compared with OHI. A. actinomycetemcomitans and T. forsythia counts were significantly lower in the NSPT group.ud
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机译：我们评估了56名中度至重度CP患者的临床变量和牙周病原微生物学特征的变化，这些患者被随机分配接受口腔卫生指导（OHI; n = 28）或非手术性牙周治疗（NSPT; n = 28）。评估牙周变量并在基线和治疗后3个月从深袋（≥5 mm）中获取龈下菌斑样品。实时聚合酶链反应用于定量放线放线杆菌，连翘坦氏菌，牙龈卟啉单胞菌和中间普氏杆菌。两组的所有临床变量均明显改善。 NSPT组在治疗后3个月，牙龈出血指数（GBI），探测袋深度（PPD）和牙周附着丧失（PAL）的改善明显更大。在基线时，所有病原体的患病率很高。在NSPT组中，放线菌和连翘菌的微生物数量显着减少（P≤0.05）。临床变量的改善均与微生物学特征的改变无关。与OHI相比，治疗3个月后，NSPT与GBI，PPD和PAL的改善显着相关。 NSPT组中放线菌和连翘的计数均显着降低。 ud
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