Gene diversity among some endogamous population of Amravati District, Maharashtra, India.

摘要

The present work deals with the distribution of ABO, Rh and sickling alleles as markers to study the genetic structure and micro-demarcation among castes and tribal populations from the Amravati district of Maharashtra. Three loci namely, ABO, Rh and sickling were selected to measure the relative frequency of respective alleles in ten (10) endogamous populations inhabiting the Amravati District. The ABO locus was found to be less polymorphic when compared with other loci. On the other hand, Rh and sickling loci were found to be more polymorphic. Construction of a dendrogram using allele frequency data reveals an interesting relationship among the caste and tribe. An analysis shows three major clades comprising A, B and C. Clade A comprises Islamic Dawoodi Bohra and Hindu Gujrati. Clade B comprises the upper castes, Brahmin, Jain, Kashmiris and Kunbis, while Clade C shows Gonds and Katchhi. This study is a first attempt to provide a genetic landscape of castes and tribes inhabiting the Vidarbha region. The findings are discussed in light of the historical, anthropological and genetic data available for the studied group.