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Brivaracetam, a selective high‐affinity synaptic vesicle protein 2A ( SV 2A) ligand with preclinical evidence of high brain permeability and fast onset of action

机译：Brivaracetam，一种选择性高亲和力突触囊泡蛋白2a（sv 2a）配体，具有高脑渗透性和快速发作的临床前验证

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Jean‐Marie Nicolas; Jonas Hannestad; Daniel Holden; Sophie Kervyn; Nabeel Nabulsi; Dominique Tytgat; Yiyun Huang; Hugues Chanteux; Ludovicus Staelens; Alain Matagne; François‐Xavier Mathy; Joël Mercier; Armel Stockis; Richard E. Carson; Henrik Klitgaard;
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1. Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action [J] . Nicolas Jean-Marie, Hannestad Jonas, Holden Daniel, Epilepsia: Journal of the International League against Epilepsy . 2016,第2期

机译：Brivaracetam，一种选择性的高亲和力突触小泡蛋白2A（SV2A）配体，具有高脑通透性和起效快的临床前证据
2. Further evidence for a differential interaction of brivaracetam and levetiracetam with the synaptic vesicle 2A protein [J] . Wood Martyn D., Sands Zara A., Vandenplas Catherine, Epilepsia: Journal of the International League against Epilepsy . 2018,第9期

机译：Brivaracetam和Levetiracetam与突触囊泡2a蛋白差异的进一步证据
3. Evidence for a differential interaction of brivaracetam and levetiracetam with the synaptic vesicle 2A protein [J] . Wood Martyn D., Gillard Michel Epilepsia: Journal of the International League against Epilepsy . 2017,第2期

机译：Brivaracetam和Levetiracetam与突触囊泡2a蛋白差异相互作用的证据
4. Combining combinatorial chemistry and affinity chromatographic for systematically probing protein-ligand interactions:application to the development of highly selective inhibitors of human betaine:homocysteine S-methyltransferase [C] . Michaela Collinsova, Carmen Castro, Timothy A.Garrow, European Peptide Symposium . 2002

机译：组合化学和亲和力色谱法系统探测蛋白 - 配体相互作用：应用于人甜菜碱的高选择性抑制剂的应用：同型半胱氨酸S-甲基转移酶
5. Biochemical and functional characterization of the interaction between the synaptic vesicle proteins SV2 and synaptotagmin. [D] . Schivell, Amanda Elizabeth. 2000

机译：突触小泡蛋白SV2和突触结合蛋白之间相互作用的生化和功能表征。
6. Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714) a high-affinity ligand for the synaptic vesicle protein SV2A [O] . A Matagne, D-G Margineanu, B Kenda, 2008

机译：Brivaracetam（UCB 34714）的抗惊厥和抗癫痫特性是突触小泡蛋白SV2A的高亲和力配体
7. Brivaracetam: Rationale for discovery and preclinical profile of a selective SV 2A ligand for epilepsy treatment [O] . Henrik Klitgaard, Alain Matagne, Jean‐Marie Nicolas, 2016

机译：Brivaracetam：选择性SV 2A配体的发现和临床前剖面的理由，用于癫痫治疗

Brivaracetam, a selective high‐affinity synaptic vesicle protein 2A ( SV 2A) ligand with preclinical evidence of high brain permeability and fast onset of action

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