首页> 外文OA文献 >Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation

【2h】

Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation

机译：N5取代的6,7-DIOxO-6,7-二氢醇作为有效和选择性表皮生长因子受体（EGFR）抑制剂对L858R / T790M电阻突变的发现和结构优化

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

著录项
引文网络
相似文献
相关主题

著录项

作者

展开▼
作者单位

展开▼
年度 -1
总页数
原文格式 PDF
正文语种
中图分类

相似文献

外文文献
中文文献
专利

1. 第一代酪氨酸激酶抑制剂治疗中发生进展的非小细胞肺癌血浆表皮生长因子受体(EGFR) T790M突变提示了失败部位并预测了临床预后:一项前瞻性观察研究 [J] . Shirong Zhang, Lucheng Zhu, Bing Xia, 癌症（英文版） . 2018,第009期
2. Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation [J] . Hao Yongjia, Wang Xia, Zhang Tao, Journal of Medicinal Chemistry . 2016,第15期

机译：N5取代的6,7-二氧-6,7-二氢蝶啶类化合物作为针对L858R / T790M耐药突变的有效和选择性表皮生长因子受体（EGFR）抑制剂的发现和结构优化
3. Discovery of novel 2,4-diarylaminopyrimidine derivatives as potent and selective epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M resistance mutation [J] . Yan Qi, Chen Yuzhe, Tang Baiyou, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2018,第期

机译：发现新型2,4-二芳基吡啶胺衍生物，作为有效的选择性表皮生长因子受体（EGFR）抑制剂免受L858R / T790M电阻突变的影响
4. Structural optimization of diphenylpyrimidine scaffold as potent and selective epidermal growth factor receptor inhibitors against L858R/T790M resistance mutation in nonsmall cell lung cancer [J] . Yi Yuanyuan, Wang Luhong, Zhao Dan, Chemical biology and drug design . 2018,第6期

机译：二苯基嘧啶支架作为有效和选择性表皮生长因子受体抑制剂对L858R / T790M抗性突变的结构优化，Nonsmall细胞肺癌
5. QSAR Study of Quinazoline Derivatives as Inhibitor of Epidermal Growth Factor Receptor-Tyrosine Kinase (EGFR-TK) [C] . La Ode Aman, Widisusanti Abdulkadir, Julitha Geybie Rembet, International Conference on Computation for Science and Technology . 2015

机译：喹唑啉衍生物作为表皮生长因子受体 - 酪氨酸激酶（EGFR-TK）抑制剂的QSAR研究
6. Epidermal growth factor receptor (EGFR) mutations and tumor-specific targeting of malignant glioma by vaccine-based immunotherapeutic approaches. [D] . Ciesielski, Michael John. 2003

机译：表皮生长因子受体（EGFR）突变和恶性神经胶质瘤的肿瘤特异性靶向通过基于疫苗的免疫治疗方法。
7. Structure-Guided Design of C4-alkyl-14-dihydro-2H-pyrimido45-d13oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors [O] . Yongjia Hao, Jiankun Lyu, Rong Qu, -1

机译：C4-烷基-14-二氢-2H-嘧啶45-d 13恶嗪-2-酮作为有效和突变体选择性表皮生长因子受体（EGFR）L858R /的结构指导设计T790M抑制剂
8. >Association Of Initial Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Treatment And EGFR Exon 19 Deletion With Frequency Of The T790M Mutation In Non-Small Cell Lung Cancer Patients After Resistance To First-Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors [O] . Wen Gao, Jing He, Shi-Dai Jin, 2019

机译：>初始表皮生长因子受体酪氨酸激酶抑制剂治疗和EGFR外显子抑制剂的抗血液抗性抗血液肺癌患者T790M突变抗性抗性后，抗抗血疱剂患者的抗性，抗抗血管生长因子受体酪氨酸激酶抑制剂

Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation

著录项

引文网络

相似文献

相关主题

期刊订阅