首页> 外文OA文献 >Focal Adhesion Kinase Inhibitors Reverse the Stromal Adhesion Phenotype of Ikaros-Mutant B-ALL, Induce Apopotosis, and Synergize with ABL1 Tyrosine Kinase Inhibitors: A New Paradigm for Pathogenesis and Therapy of High-Risk B-ALL

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Focal Adhesion Kinase Inhibitors Reverse the Stromal Adhesion Phenotype of Ikaros-Mutant B-ALL, Induce Apopotosis, and Synergize with ABL1 Tyrosine Kinase Inhibitors: A New Paradigm for Pathogenesis and Therapy of High-Risk B-ALL

机译：局灶性粘附激酶抑制剂逆转Ikaros-突变体B-全部，诱导传象症的基质粘附表型，并用Abl1酪氨酸激酶抑制剂进行协同作用：高风险的发病机制和治疗的新范式

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Ila Joshi; Nilamani Jena; Toshimi Yoshida; Leto Paraskevopoulou; Zhihong Zhang; Zhong-Ying Liu; Shane Korber; Daniela S. Krause; Irina M. Shapiro; David T. Weaver; Jonathan A. Pachter; Elisabeth M. Paietta; Richard A. Van Etten; Katia Georgopoulos;
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1. Phosphotyrosine enrichment identifies focal adhesion kinase and other tyrosine kinases for targeting in canine hemangiosarcoma. (Special Issue: Tyrosine kinase inhibitors.) [J] . Marley K., Maier C. S., Helfand S. C. Veterinary and Comparative Oncology . 2012,第3期

机译：磷酸酪氨酸富集可鉴定出靶向犬血管瘤肉瘤的粘着斑激酶和其他酪氨酸激酶。（特刊：酪氨酸激酶抑制剂。）
2. Focal adhesion kinase-related nonkinase inhibits vascular smooth muscle cell invasion by focal adhesion targeting, tyrosine 168 phosphorylation, and competition for p130(Cas) binding. [J] . Koshman YE, Chu M, Engman SJ, Arteriosclerosis, thrombosis, and vascular biology . 2011,第11期

机译：粘着斑激酶相关的非激酶通过粘着斑靶向，酪氨酸168磷酸化和竞争p130（Cas）结合抑制血管平滑肌细胞的侵袭。
3. Oncogenic Receptor Tyrosine Kinases Directly Phosphorylate Focal Adhesion Kinase (FAK) as a Resistance Mechanism to FAK-Kinase Inhibitors [J] . Marlowe Timothy A., Lenzo Felicia L., Figel Sheila A., Molecular cancer therapeutics . 2016,第12期

机译：致癌性受体酪氨酸激酶直接磷酸化局灶性粘附激酶（FAK）作为对FAK激酶抑制剂的耐药机制。
4. THE ABL-RELATED GENE (ARG) TYROSINE KINASE ATTENUATES CELL MIGRATION BY INHIBITING ACTOMYOSIN CONTRACTILITY AND REGULATING FOCAL ADHESION DYNAMICS [C] . Justin G. Peacock, Ann L. Miller, William D. Bradley, Adhesion Society, Inc. Annual Meeting; 20070218-21; Tampa Bay,FL(US) . 2007

机译：ABL相关基因（ARG）酪氨酸激酶通过抑制肌动蛋白的可收缩性和调节局部黏附动力学来减轻细胞迁移
5. The multi-targeted receptor tyrosine kinase inhibitor, linifanib (ABT-869), induces apoptosis and inhibits proliferation of leukemia cells through phosphoinositide-3 kinase (PI3K)/AKT-dependent signaling pathways. [D] . Hernandez, Jenny Elizabeth. 2010

机译：多靶点受体酪氨酸激酶抑制剂利尼法尼（ABT-869）通过磷酸肌醇3激酶（PI3K）/ AKT依赖性信号传导途径诱导凋亡并抑制白血病细胞的增殖。
6. Focal Adhesion Kinase Inhibitor Inhibits the Oxidative Damage Induced by Central Venous Catheter via Abolishing Focal Adhesion Kinase-Protein Kinase B Pathway Activation [O] . Yanru Wang, Sulan Lin, Ping Jiang, 2021

机译：局灶性粘附激酶抑制剂通过废除局灶性粘附激酶 - 蛋白激酶B途径激活来抑制中枢静脉导管诱导的氧化损伤
7. Induced Focal Adhesion Kinase (FAK) Expression in FAK-Null Cells Enhances Cell Spreading and Migration Requiring Both Auto- and Activation Loop Phosphorylation Sites and Inhibits Adhesion-Dependent Tyrosine Phosphorylation of Pyk2 [O] . Owen, James D., Ruest, Paul J., Fry, David W., 1999

机译：在FAK空细胞中诱导的局灶性粘附激酶（FAK）表达增强细胞的扩散和迁移，需要自动和激活环磷酸化位点，并抑制Pyk2的粘附依赖性酪氨酸磷酸化。

Focal Adhesion Kinase Inhibitors Reverse the Stromal Adhesion Phenotype of Ikaros-Mutant B-ALL, Induce Apopotosis, and Synergize with ABL1 Tyrosine Kinase Inhibitors: A New Paradigm for Pathogenesis and Therapy of High-Risk B-ALL

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