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Single-Cell Pharmacodynamic Monitoring of S6 Ribosomal Protein Phosphorylation in AML Blasts during a Clinical Trial Combining the mTOR Inhibitor Sirolimus and Intensive Chemotherapy

机译：MTOR抑制剂西罗莫司和强化化疗的临床试验期间AML爆炸中S6核糖体蛋白磷酸化的单细胞药效监测

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Alexander E. Perl; Margaret T. Kasner; Doris Shank; Selina M. Luger; Martin Carroll;
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年度 2011
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1. Single-cell pharmacodynamic monitoring of S6 ribosomal protein phosphorylation in AML blasts during a clinical trial combining the mTOR inhibitor sirolimus and intensive chemotherapy [J] . PerlA.E., KasnerM.T., ShankD., Clinical cancer research: an official journal of the American Association for Cancer Research . 2012,第6期

机译：结合mTOR抑制剂西罗莫司和强化化疗的临床试验期间，单细胞药代动力学监测AML母细胞中S6核糖体蛋白磷酸化
2. Performance of a phosphoflow assay to determine phosphorylation of S6 ribosomal protein as a pharmacodynamic read out for mTOR inhibition [J] . Abdel-Kahaar Emaad, Kabakchiev Mariana, Hartmann Bertram, Clinical Biochemistry . 2016,第15期

机译：进行磷流测定以确定S6核糖体蛋白磷酸化的性能，作为读出mTOR抑制的药效学读数
3. Effect of confounding factors on a phospho-flow assay of ribosomal S6 protein for therapeutic drug monitoring of the mTOR-inhibitor everolimus in heart transplanted patients [J] . Dieterlen Maja-Theresa, John Katja, Haase Susanne, Biomarkers . 2017,第1a8期

机译：混杂因子对核糖体S6蛋白磷酸流测定的影响，以监测mTOR抑制剂依维莫司治疗心脏移植患者的疗效
4. Single-cell Pharmacodynamic Monitoring of S6 Ribosomal Protein Phosphorylation in AML Blasts During a Clinical Trial Combining the mTOR Inhibitor Sirolimus and Intensive Chemotherapy [O] . Alexander E. Perl, Margaret T. Kasner, Doris Shank, -1

机译：在amL细胞s6核糖体蛋白磷酸化的单细胞药效监测期间临床试验相结合的mTOR抑制剂西罗莫司和强烈化疗
5. Rabin8 Protein Interacts with GTPase Rheb and Inhibits Phosphorylation of Ser235/Ser236 in Small Ribosomal Subunit Protein S6 [O] . А А Parkhitko, О О Favorova, E P Henske 2011

机译：Rabin8蛋白与GTPAse RhEB相互作用，并抑制Ser235 / Ser236在小核糖体亚基蛋白S6中的磷酸化

Single-Cell Pharmacodynamic Monitoring of S6 Ribosomal Protein Phosphorylation in AML Blasts during a Clinical Trial Combining the mTOR Inhibitor Sirolimus and Intensive Chemotherapy

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