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An anti-EGFR × cotinine bispecific antibody complexed with cotinine-conjugated duocarmycin inhibits growth of EGFR-positive cancer cells with KRAS mutations

机译：含有胞苷缀合的二肢霉素络合的抗EGFR×Cotinine双特异性抗体抑制了kras突变的Egfr阳性癌细胞的生长

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Junyeong Jin; Gunwoo Park; Jong Bae Park; Soohyun Kim; Hyori Kim; Junho Chung;
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1. An anti-EGFR?×?cotinine bispecific antibody complexed with cotinine-conjugated duocarmycin inhibits growth of EGFR-positive cancer cells with KRAS mutations [J] . Junyeong Jin, Gunwoo Park, Jong Bae Park, Experimental & molecular medicine. . 2018,第5期

机译：与可替宁偶联的杜卡霉素复合的抗EGFRα×烟碱双特异性抗体可抑制具有KRAS突变的EGFR阳性癌细胞的生长
2. Bispecific anti-mPDGFR beta x cotinine scFv-C-kappa-scFv fusion protein and cotinine-duocarmycin can form antibody-drug conjugate-like complexes that exert cytotoxicity against mPDGFR beta expressing cells [J] . Kim Soohyun, Kim Hyori, Jo Dong Hyun, Methods: A Companion to Methods in Enzymology . 2019,第期

机译：双特异性抗MPDGFRβX Cotinine ScFv-C-Kappa-SCFV融合蛋白和Cotinine-Duocarmycin可以形成抗体 - 药物缀合物样络合物，其施加对MPDGFRβ表达细胞的细胞毒性
3. Bispecific anti-mPDGFR beta x cotinine scFv-C kappa-scFv fusion protein and cotinine-duocarmycin can form antibody-drug conjugate-like complexes that exert cytotoxicity against mPDGFR beta expressing cells (vol 154, pg 125, 2019) [J] . Kim Soohyun, Kim Hyori, Jo Dong Hyun, Methods: A Companion to Methods in Enzymology . 2019,第期

机译：双特异性抗MPDGFRβX Cotinine SCV-Cκ-SCFV融合蛋白和Cotinine-Duocarmycin可以形成抗体 - 药物缀合物样络合物，其施加对MPDGFRβ表达细胞的细胞毒性（Vol 154，PG 125,2019）
4. Simulations of the EGFR - KRAS - MAPK Signalling Network in Colon Cancer. Virtual Mutations and Virtual Treatments with Inhibitors Have More Important Effects Than a 10 Times Range of Normal Parameters and Rates Fluctuations [C] . Nicoletta Castagnino, Lorenzo Tortolina, Roberto Montagna, International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics . 2010

机译：EGFR - KRAS - MAPK信号网络在结肠癌中的模拟。具有抑制剂的虚拟突变和虚拟处理具有比正常参数范围的10倍的更重要的效果和速率波动
5. Pharmacology Profiles of ALK and FLT3 Kinase Inhibitors against Non-Small-Cell Lung Cancer Cells and Acute Myeloid Leukemia Cells with Cancer Driver Mutations [D] . 森政道 2019

机译：ALK和FLT3激酶抑制剂对非小细胞肺癌细胞和急性髓系白血病细胞的癌症驱动突变的药理作用
6. An anti-EGFR × cotinine bispecific antibody complexed with cotinine-conjugated duocarmycin inhibits growth of EGFR-positive cancer cells with KRAS mutations [O] . Junyeong Jin, Gunwoo Park, Jong Bae Park, 2018

机译：抗EGFR×烟碱双特异性抗体与可替宁偶联的杜卡霉素复合可抑制具有KRAS突变的EGFR阳性癌细胞的生长
7. PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis [O] . C. Mao, Z.Y. Yang, X.F. Hu, 2012

机译：Pik3Ca Exon 20突变作为潜在的抗EGFR单克隆抗体在KRAS野生型转移性结肠直肠癌中的潜在生物标志物：系统审查和荟萃分析
8. Systematic Reviews on Selected Pharmacogenetic Tests for Cancer Treatment: CYP2D6 for Tamoxifen in Breast Cancer, KRAS for anti-EGFR antibodies in Colorectal Cancer, and BCR-ABL1 for Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia. Technology Assessment Report [R] . Terasawa, T., Dahabreh, I., Castaldi, P. J., 2010

机译：针对癌症治疗的选定药物遗传学测试的系统评价：CYp2D6用于乳腺癌中的他莫昔芬，KRas用于结肠直肠癌中的抗EGFR抗体，以及BCR-aBL1用于慢性髓性白血病中的酪氨酸激酶抑制剂。技术评估报告

An anti-EGFR × cotinine bispecific antibody complexed with cotinine-conjugated duocarmycin inhibits growth of EGFR-positive cancer cells with KRAS mutations

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