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Activation of 4-hydroxytamoxifen and the tamoxifen derivative metabolite E by uterine peroxidase to form DNA adducts: Comparison with DNA adducts formed in the uterus of Sprague-Dawley rats treated with tamoxifen

机译：用子宫过氧化物酶活化4-羟基氧酰胺和三氧肟衍生物代谢物E形成DNA加合物：与用Tamoxifen处理的Sprague-Dawley大鼠子宫中形成的DNA加合物的比较

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Deena N. Pathak; Krisztina Pongracz; William J. Bodell;
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年度 1996
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1. Peroxidase-mediated dealkylation of tamoxifen, detected by electrospray ionization-mass spectrometry, and activation to form DNA adducts [J] . GaikwadN.W., BodellW.J. Free Radical Biology and Medicine: The Official Journal of the Oxygen Society . 2012,第2期

机译：通过电喷雾电离质谱法检测过氧化物酶介导的他莫昔芬脱烷基，并活化形成DNA加合物
2. Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment. [J] . Phillips DH, Hewer A, Osborne MR, Mutagenesis . 2005,第4期

机译：他莫昔芬和α-羟基他莫昔芬在大鼠中形成DNA加合物的器官特异性：对于了解他莫昔芬致癌性机理和人类风险评估的意义。
3. Formation of tamoxifen-DNA adducts via O-sulfonation, not O-acetylation, of alpha-hydroxytamoxifen in rat and human livers. [J] . Kim SY, Laxmi YR, Suzuki N, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2005,第11期

机译：他莫昔芬-DNA加合物通过大鼠和人类肝脏中的α-羟基他莫昔芬的O-磺化而不是O-乙酰化而形成。
4. Aflatoxin-DNA Adducts as Biomarkers of Cancer:Nature, Formation, Kinds of AF—DNA Adducts,Methodology, Effects, and Control [C] . Magda Carvajal Symposia on Mycotoxins and Food Allergens . 2008

机译：黄曲霉毒素-DNA加合物作为癌症的生物标志物：性质，形成，种类的AF-DNA加合物，方法，效果和控制
5. In vivo and in vitro comparison of cytochrome P-450 expression and DNA adduct formation in rat liver and lung treated with benzo(a)pyrene. [D] . Hand, Jeanine Ann. 2001

机译：体内和体外比较用苯并（a）treated处理的大鼠肝和肺中细胞色素P-450表达和DNA加合物的形成。
6. Peroxidase mediated dealkylation of Tamoxifen detected by ESI-MS and activation to form of DNA adducts [O] . Nilesh W. Gaikwad, William J. Bodell -1

机译：过氧化物酶通过ESI-MS检测到的Tamoxifen的过氧化物酶介导并激活DNA加合物的形式
7. DNA adduct formation and mutant induction in Sprague-Dawley rats treated with tamoxifen and its derivatives [O] . G. Gamboa da Costa 2001

机译：用Tamoxifen及其衍生物处理的Sprague-Dawley大鼠中的DNA加合形成和突变诱导

Activation of 4-hydroxytamoxifen and the tamoxifen derivative metabolite E by uterine peroxidase to form DNA adducts: Comparison with DNA adducts formed in the uterus of Sprague-Dawley rats treated with tamoxifen

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