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Tolerability, Safety, and Quality of Life with Tapentadol Prolonged Release ( PR ) Compared with Oxycodone/Naloxone PR in Patients with Severe Chronic Low Back Pain with a Neuropathic Component: A Randomized, Controlled, Open‐label, Phase 3b/4 Trial

机译：与神经病成分严重慢性低腰疼痛患者的羟考酮/纳洛酮PR相比，Tapentadol延长释放（PR）的耐受性，安全性和生活质量（Pr）：随机，受控，开放标签，第3B / 4阶段试验

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Ralf Baron; Jan‐Peter Jansen; Andreas Binder; Manuel Pombo‐Suarez; Lieven Kennes; Matthias Müller; Dietmar Falke; Ilona Steigerwald;
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1. Effectiveness and safety of tapentadol prolonged release for severe, chronic low back pain with or without a neuropathic pain component: Results of an open-label, phase 3b study [J] . SteigerwaldI., MüllerM., DaviesA., Current medical research and opinion . 2012,第6期

机译：他喷他多延长释放对有或没有神经性疼痛成分的严重，慢性下腰痛的有效性和安全性：3b期开放标签研究的结果
2. Driving Ability in Patients with Severe Chronic Low Back or Osteoarthritis Knee Pain on Stable Treatment with Tapentadol Prolonged Release: A Multicenter, Open-label, Phase 3b Trial [J] . Rainer Sabatowski, Rüdiger Scharnagel, Anne Gyllensv?rd, Pain and therapy. . 2014,第1期

机译：重度慢性腰背痛或骨关节炎膝痛患者使用他喷他多缓释稳定治疗的驾驶能力：一项多中心，开放标签的3b期临床试验
3. Effectiveness and safety of tapentadol prolonged release with tapentadol immediate release on-demand for the management of severe, chronic osteoarthritis-related knee pain: results of an open-label, phase 3b study [J] . Ilona Steigerwald, Matthias Müller, Jolanta Kujawa, Journal of Pain Research . 2012,第2期

机译：他喷他多延长释放与他喷他多按需即时释放治疗严重的，慢性骨关节炎相关的膝关节疼痛的有效性和安全性：一项开放式3b期研究的结果
4. Randomized controlled trial comparing of analgesic effectiveness of TPRF and TENs in clinical and endocrinological changes for chronic shoulder pain [C] . Lin Mu-Lien, Luo Yuan-Jie, Hsu Yu-Ming, 4th International Symposium on Bioelectronics and Bioinformatics . 2015

机译：TPRF和TENs对慢性肩痛的临床和内分泌变化镇痛效果的随机对照试验
5. A Comparison Between Stabilization Exercises and Stabilization Exercises Supplemented with Neuromuscular Electrical Stimulation in Patients with Chronic Low Back Pain: A Phase I Randomized Controlled Trial [D] . Alrwaily, Muhammad. 2017

机译：慢性腰背痛患者稳定运动与稳定运动加神经肌肉电刺激的比较：I期随机对照试验
6. Effectiveness and safety of tapentadol prolonged release with tapentadol immediate release on-demand for the management of severe chronic osteoarthritis-related knee pain: results of an open-label phase 3b study [O] . Ilona Steigerwald, Matthias Müller, Jolanta Kujawa, 2012

机译：他喷他多延长释放与他喷他多按需即时释放治疗严重的慢性骨关节炎相关的膝关节疼痛的有效性和安全性：一项开放式3b期研究的结果
7. Efficacy and tolerability balance of oxycodone/naloxone and tapentadol in chronic low back pain with a neuropathic component: a blinded end point analysis of randomly selected routine data from 12-week prospective open-label observations [O] . Michael Ueberall, Gerhard Mueller-Schwefe 2016

机译：羟考酮/纳洛酮和Tapentadol的疗效和耐受性平衡在慢性低腰疼痛中具有神经性组分：从12周前瞻性开放标签观测到随机选择的常规数据的盲终点分析

Tolerability, Safety, and Quality of Life with Tapentadol Prolonged Release ( PR ) Compared with Oxycodone/Naloxone PR in Patients with Severe Chronic Low Back Pain with a Neuropathic Component: A Randomized, Controlled, Open‐label, Phase 3b/4 Trial

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