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Expression of herstatin, an autoinhibitor of HER-2/neu, inhibits transactivation of HER-3 by HER-2 and blocks EGF activation of the EGF receptor

机译：HERSTATIN，HER-2 / NEU的自身抑制剂的表达抑制了HER-3的转发，并阻断EGF受体的EGF活化

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Nicolas G Azios; Farida Jhabvala Romero; Michael C Denton; Joni K Doherty; Gail M Clinton;
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2. Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers [J] . Said A Khelwatty, Sharadah Essapen, Alan M Seddon, British Journal of Cancer . 2015,第7期

机译：在癌细胞中获得的对抗EGFR mAb ICR62的耐药性伴随着EGFR表达增加，HER-2 / HER-3信号传导以及对泛HER阻滞剂的敏感性增加
3. Amplifications of EGFR gene and protein expression of EGFR, Her-2|[sol]|neu, c-kit, and androgen receptor in phyllodes tumor of the prostate [J] . Xiaoyan Wang, Timothy D Jones, Shaobo Zhang, Modern Pathology . 2007,第2期

机译：前列腺叶状肿瘤中EGFR基因的扩增和EGFR，Her-2 | [sol] | neu，c-kit和雄激素受体的蛋白表达
4. EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations [J] . Rohit Bhargava, William L Gerald, Allan R Li, Modern Pathology . 2005,第8期

机译：乳腺癌中的EGFR基因扩增：与表皮生长因子受体mRNA和蛋白表达以及HER-2状态和不存在EGFR激活突变的相关性
5. Combination Treatment with Her-2 and VEGF Peptide Mimics Induces Potent Anti-Tumor and Anti-Angiogenic Responses In Vitro and In Vivo [C] . Kevin C. Foy, Zhenzhen Liu, Sharad Rawale American Peptide Symposium . 2009

机译：用HER-2和VEGF肽模拟物的组合治疗诱导体外和体内有效的抗肿瘤和抗血管生成反应
6. An antagonist of the prostaglandin F2alpha receptor (FP)-Galphaq-dependent response, biases FP into mitogen-activated protein kinase (MAPK) signalling through epidermal growth factor receptor (EGFR) transactivation . [D] . Wisehart, Veronica. 2011

机译：前列腺素F2alpha受体（FP）-Galphaq依赖性反应的拮抗剂通过表皮生长因子受体（EGFR）反式激活将FP偏向促分裂原激活的蛋白激酶（MAPK）信号传导。
7. Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression HER-2/HER-3 signalling and sensitivity to pan HER blockers [O] . Said A Khelwatty, Sharadah Essapen, Alan M Seddon, 2015

机译：在癌细胞中获得的对抗EGFR mAb ICR62的耐药性伴随着EGFR表达增加HER-2 / HER-3信号传导增强以及对泛HER阻滞剂的敏感性
8. Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers. [O] . Khelwatty Said A., Essapen Sharadah, Seddon Alan M., 2015

机译：在癌细胞中获得对抗EGFR mab ICR62的抗性伴随着EGFR表达增加，HER-2 / HER-3信号传导和对泛HER阻断剂的敏感性。

Expression of herstatin, an autoinhibitor of HER-2/neu, inhibits transactivation of HER-3 by HER-2 and blocks EGF activation of the EGF receptor

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