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ActivinA Induced SMAD1/5 Signaling in an iPSC Derived EC Model of Fibrodysplasia Ossificans Progressiva (FOP) Can Be Rescued by the Drug Candidate Saracatinib

机译：Activina诱导的Smad1 / 5信号在IPSC衍生的纤维素类化合物的EC模型中，可以通过药物候选Saracatinib来救出

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Susanne Hildebrandt; Branka Kampfrath; Kristin Fischer; Laura Hildebrand; Julia Haupt; Harald Stachelscheid; Petra Knaus;
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1. The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling [J] . Emilie Barruet, Blanca M. Morales, Wint Lwin, Stem Cell Research & Therapy . 2016,第1期

机译：在骨增生性纤维增生中发现ACVR1 R206H突变可通过BMP介导的SMAD1 / 5/8信号增加人诱导的多能干细胞衍生的内皮细胞形成和胶原蛋白的产生
2. The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling [J] . Emilie Barruet, Blanca M. Morales, Wint Lwin, Stem Cell Research & Therapy . 2016,第1期

机译：在骨增生性纤维增生中发现ACVR1 R206H突变可通过BMP介导的SMAD1 / 5/8信号增加人诱导的多能干细胞衍生的内皮细胞形成和胶原蛋白的产生
3. Activin A amplifies dysregulated BMP signaling and induces chondroosseous differentiation of primary connective tissue progenitor cells in patients with fibrodysplasia ossificans progressiva (FOP) [J] . Wang Haitao, Shore Eileen M., Pignolo Robert J., Bone . 2018,第期

机译：激活蛋白酶诱导纤维单胰腺骨质人进化（FOP）患者患者患者诱导初级结缔组织祖细胞的软骨静脉分化
4. A multipathway phosphoproteomic signaling network model of idiosyncratic drug- and inflammatory cytokine-induced toxicity in human hepatocytes [C] . Benjamin D. Cosgrove, Leonidas G. Alexopoulos, Julio Saez-Rodriguez, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2009

机译：一种多发性磷酸磷蛋白酶信号网络模型的人肝细胞瘤和炎症细胞因子诱导的毒性
5. Generation of Induced Pluripotent Stem Cell Derived Endothelial Cells from Fibrodysplasia Ossificans Progressiva Patients - A Disease Model of ActivinA and BMP-Induced ALK2 Receptor Activation =Generierung von Endothelzellen aus induzierten pluripotenten [D] . Hildebrandt, Susanne. 2020

机译：生成诱导多能干细胞衍生的纤维型胰腺类骨质人进化患者的内皮细胞 - Activina和BMP诱导的Alk2受体激活=普通钨患者的疾病模型= Induzierten ploripotenten
6. The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling [O] . Emilie Barruet, Blanca M. Morales, Wint Lwin, 2016

机译：在骨增生性纤维增生中发现ACVR1 R206H突变可通过BMP介导的SMAD1 / 5/8信号增加人诱导的多能干细胞衍生的内皮细胞形成和胶原蛋白的产生
7. The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling [O] . Emilie Barruet, Blanca M. Morales, Wint Lwin, 2016

机译：在骨增生性纤维增生中发现ACVR1 R206H突变可通过BMP介导的SMAD1 / 5/8信号增加人诱导的多能干细胞衍生的内皮细胞形成和胶原蛋白的产生

ActivinA Induced SMAD1/5 Signaling in an iPSC Derived EC Model of Fibrodysplasia Ossificans Progressiva (FOP) Can Be Rescued by the Drug Candidate Saracatinib

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