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Synthesis of novel pyridine and pyrimidine derivatives as potential inhibitors of HIV-1 reverse transcriptase using palladium-catalysed C-N cross-coupling and nucleophilic aromatic substitution reactions

机译：用钯催化的C-N交叉偶联和亲核芳族取代反应为HIV-1逆转录酶的潜在抑制剂的合成新的吡啶和嘧啶衍生物

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Charles R. K. Changunda; Amanda L. Rousseau; Adriaan E. Basson; Moira L. Bode;
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年度 2021
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1. Synthesis and HIV-1 reverse transcriptase inhibitor activity of some 2,5,6-substituted benzoxazole, benzimidazole, benzothiazole and oxazolo(4,5-b)pyridine derivatives. [J] . Akbay A, Oren I, Temiz Arpaci O, Arzneimittel-Forschung: =Drug Research . 2003,第4期

机译：一些2,5,6-取代的苯并恶唑，苯并咪唑，苯并噻唑和恶唑并（4,5-b）吡啶衍生物的合成及其HIV-1逆转录酶抑制剂的活性。
2. Discovery of piperidine-substituted thiazolo[5,4- d ]pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors [J] . Dongwei Kang, Tong Zhao, Zhao Wang, Communications Chemistry . 2019,第1期

机译：发现哌啶 - 取代的噻唑啉[5,4- D]嘧啶衍生物作为有效和口服生物可利用的HIV-1非核苷逆转录酶抑制剂
3. Regioselective cross-coupling reactions and nucleophilic aromatic substitutions on a 5,7-dichloro-pyrido[4,3-d|pyrimidine scaffold [J] . Mi-Yeon Jang, Steven De Jonghe, Ling-Jie Gao Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2006,第50期

机译：5,7-二氯-吡啶并[4,3-d |嘧啶]支架上的区域选择性交叉偶联反应和亲核芳族取代
4. Diarylaniline Derivatives as a Distinct Class of HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors [C] . Bingjie Qin, Shibo Jiang, Kuo-Hsiung Lee, ICMSI;International conference of molecular simulations and applied informatics technologies . 2010

机译：二芳基苯胺衍生物作为HIV-1非核苷逆转录酶抑制剂的一类。
5. A. Studies towards the formation of asymmetric quaternary centres via radical allylation. B. Applications of chiral hydrazide organocatalysts to Diels-Alder, hydride reduction, and alpha-chlorination reactions. C. Studies directed towards the synthesis of potential HIV-1 reverse transcriptase inhibitors: 9-Alkylaryl TIBO derivatives. [D] . Aumand, Livia M. 2005

机译：A.关于通过自由基烯丙基化形成不对称四元中心的研究。 B.手性酰肼有机催化剂在Diels-Alder，氢化物还原和α-氯化反应中的应用。 C.针对潜在的HIV-1逆转录酶抑制剂的合成的研究：9-烷基芳基TIBO衍生物。
6. Synthesis and Biological Evaluation of Novel 2-Arylalkylthio-5-iodine-6-substituted-benzyl-pyrimidine-4(3H)-ones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors [O] . Liang Zhang, Xiaowan Tang, Yuanyuan Cao, 2014

机译：新型2-芳烷基硫基-5-碘-6-取代的苄基-嘧啶-4（3H）-作为强效HIV-1非核苷逆转录酶抑制剂的合成及生物学评价
7. Synthesis and Biological Evaluation of Novel 2-Arylalkylthio-5-iodine-6-substituted-benzyl-pyrimidine-4(3H)-ones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors [O] . Liang Zhang, Xiaowan Tang, Yuanyuan Cao, 2014

机译：新型2-芳基烷硫基-5-碘-6-取代 - 苄基 - 嘧啶-4（3H） - 酮作为有效的HIV-1非核苷类逆转录酶抑制剂的合成和生物学评价

Synthesis of novel pyridine and pyrimidine derivatives as potential inhibitors of HIV-1 reverse transcriptase using palladium-catalysed C-N cross-coupling and nucleophilic aromatic substitution reactions

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