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Antibody–Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies

机译：含有吡咯洛洛二嗪珠或管蛋白有效载荷的抗体 - 药物缀合物是免疫调节性的，并用多种免疫治疗来协同增量

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Jonathan Rios-Doria; Jay Harper; Raymond Rothstein; Leslie Wetzel; Jon Chesebrough; Allison Marrero; Cui Chen; Patrick Strout; Kathy Mulgrew; Kelly McGlinchey; Ryan Fleming; Binyam Bezabeh; John Meekin; David Stewart; Maureen Kennedy; Philip Martin; Andrew Buchanan; Nazzareno Dimasi; Emil Michelotti; Robert Hollingsworth;
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1. Antibody-Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies [J] . Rios-Doria Jonathan, Harper Jay, Rothstein Raymond, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2017,第10期

机译：含有吡咯洛洛二嗪珠或管蛋白有效载荷的抗体 - 药物缀合物是免疫调节性的，并用多种免疫治疗来协同增量
2. Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody-Drug Conjugates [J] . K. C. Nicolaou, Rohan D. Erande, Jun Yin, Journal of the American Chemical Society . 2018,第10期

机译：改进的Tubulysins的总合成以及对癌细胞具有高度有效细胞毒性的新型Tubulysins的设计，合成和生物学评估，这是潜在的抗体药物结合物
3. The Development and Scale-Up of an Antibody Drug Conjugate Tubulysin Payload [J] . Parker Jeremy S., McCormick Marc, Anderson David W., Organic process research & development . 2017,第10期

机译：抗体药物共轭管蛋白有效载荷的开发和扩展
4. KTN0182A, an Anti-KIT, Pyrrolobenzodiazepine (PBD)-Containing Antibody Drug Conjugate (ADC) Demonstrates Potent Antitumor Activity In Vitro and In Vivo Against a Broad Range of Tumor Types [C] . Sergio Trombetta, Christine Lubeski, Gary C. Kemp, PEGS . 2015

机译：KTN0182A，抗试剂盒，吡咯唑二氮杂己酮（PBD）抗体药物缀合物（ADC）在体外和体内抗抗肿瘤类型的抗肿瘤活性
5. Investigations into the Development of Epothilones as Antibody-Drug Conjugate Payloads [D] . Imlay, Hunter David. 2020

机译：作为抗体 - 药物共轭有效载荷的表现为赤素酮的发展
6. Pre-clinical pharmacology and mechanism of action of SG3199 the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine [O] . John A. Hartley, Michael J. Flynn, John P. Bingham, -1

机译：药物-药物偶联物（ADC）有效载荷tesirine的吡咯并苯并二氮杂（PBD）二聚体战斗部组分SG3199的临床前药理学和作用机理
7. Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload [O] . Arnaud C. Tiberghien, Jean-Noel Levy, Luke A. Masterson, 2016

机译：Tesirine的设计和合成，临床抗体 - 药物缀合物吡咯唑二氮杂卓二聚体有效载荷

Antibody–Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies

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