首页> 外文OA文献 >Synthesis and Anti-Renal Fibrosis Activity of Conformationally Locked Truncated 2-Hexynyl-N6-Substituted-(N)-Methanocarba-nucleosides as A3 Adenosine Receptor Antagonists and Partial Agonists

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Synthesis and Anti-Renal Fibrosis Activity of Conformationally Locked Truncated 2-Hexynyl-N6-Substituted-(N)-Methanocarba-nucleosides as A3 Adenosine Receptor Antagonists and Partial Agonists

机译：组合锁定截短的2-己酰基-N6-取代 - （n） - 甲烷的纤维化活性为A3腺苷受体拮抗剂和部分激动剂的抗肾纤维化活性

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Akshata Nayak; Girish Chandra; Inah Hwang; Kyunglim Kim; Xiyan Hou; Hea Ok Kim; Pramod K. Sahu; Kuldeep K. Roy; Jakyung Yoo; Yoonji Lee; Minghua Cui; Sun Choi; Steven M. Moss; Khai Phan; Zhan-Guo Gao; Hunjoo Ha; Kenneth A. Jacobson; Lak Shin Jeong;
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1. Synthesis and Anti-Renal Fibrosis Activity of Conformationally Locked Truncated 2?Hexynyl?N~6?Substituted?(N)?Methanocarbanucleosides as A_3 Adenosine Receptor Antagonists and Partial Agonists [J] . Akshata Nayak, Girish Chandra, Inah Hwang, Journal of Medicinal Chemistry . 2014,第4期

机译：构型锁定截短的2？己炔基？N〜6？取代的？（N）？甲氨基甲酸核苷作为A_3腺苷受体拮抗剂和部分激动剂的合成及抗肾纤维化活性。
2. Correlation study between A(3) adenosine receptor binding affinity and anti-renal interstitial fibrosis activity of truncated adenosine derivatives [J] . Yu Jinha, Kim Gyudong, Jarhad Dnyandev B., Archives of pharmacal research . 2019,第9期

机译：截断腺苷衍生物的（3）腺苷受体结合亲和力与抗肾间质纤维化活性的相关性研究
3. Interaction of SSR161421, a novel specific adenosine A3 receptor antagonist with adenosine A3 receptor agonists both in vitro and in vivo [J] . MikusE.G., BoérK., TimáriG., European Journal of Pharmacology: An International Journal . 2013,第1a3期

机译：SSR161421的相互作用，一种新的特异性腺苷A3受体拮抗剂，腺苷A3受体激动剂在体外和体内
4. QSAR Analysis of Human Adenosine A3 Receptor Antagonists [C] . QIAO Kang, ZENG Ling-Xiao, JIN Hong-Wei, International conference of molecular simulations and applied informatics technologies . 2012

机译：人腺苷A3受体拮抗剂的QSAR分析
5. Synthesis and biological evaluation of conformationally constrained sphingosine-1-phosphate analogs as subtype selective S1P receptor agonist/antagonist. [D] . Zhu, Ran. 2008

机译：构象受限的鞘氨醇-1-磷酸类似物作为亚型选择性S1P受体激动剂/拮抗剂的合成和生物学评估。
6. Polypharmacology of N6-(3-Iodobenzyl)adenosine-5′-N-methyluronamide (IB-MECA) and Related A3 Adenosine Receptor Ligands: Peroxisome Proliferator Activated Receptor (PPAR) γ Partial Agonist and PPARδ Antagonist Activity Suggests Their Antidiabetic Potential [O] . Jinha Yu, Seyeon Ahn, Hee Jin Kim, -1

机译：N6-（3-碘苄基）腺苷-5-N-甲基脲酰胺（IB-MECA）和相关的A3腺苷受体配体的多药理学：过氧化物酶体增殖物激活受体（PPAR）γ部分激动剂和PPARδ拮抗剂的活性表明其抗糖尿病潜力
7. Truncated (N)-Methanocarba Nucleosides as Partial Agonists at Mouse and Human A3 Adenosine Receptors: Affinity Enhancement by N6(2-Phenylethyl) Substitution [O] . -1

机译：截短的（n）-methanocarba核苷作为小鼠和人A3腺苷受体的局部激动剂：N6（2-苯基乙基）取代的亲和增强

Synthesis and Anti-Renal Fibrosis Activity of Conformationally Locked Truncated 2-Hexynyl-N6-Substituted-(N)-Methanocarba-nucleosides as A3 Adenosine Receptor Antagonists and Partial Agonists

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