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Clinical and Biological Effects of Valproic Acid as a Histone Deacetylase Inhibitor on Tumor and Surrogate Tissues: Phase I/II Trial of Valproic acid and Epirubicin/FEC

机译：丙戊酸作为肿瘤和替代组织组蛋白脱乙酰酶抑制剂的临床和生物学效应：丙甲酸和表皮蛋白/ FEC的I / II试验

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Pamela Munster; Douglas Marchion; Elona Bicaku; Mira Lacevic; Jongphil Kim; Barbara Centeno; Adil Daud; Anthony Neuger; Susan Minton; Daniel Sullivan;
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年度 2009
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1. Clinical and biological effects of valproic acid as a histone deacetylase inhibitor on tumor and surrogate tissues: phase I/II trial of valproic acid and epirubicin/FEC. [J] . Munster P, Marchion D, Bicaku E, Clinical cancer research: an official journal of the American Association for Cancer Research . 2009,第7期

机译：丙戊酸作为组蛋白脱乙酰基酶抑制剂对肿瘤和替代组织的临床和生物学作用：丙戊酸和表柔比星/ FEC的I / II期试验。
2. Phase I trial of histone deacetylase inhibition by valproic acid followed by the topoisomerase II inhibitor epirubicin in advanced solid tumors: a clinical and translational study. [J] . Munster P, Marchion D, Bicaku E, Journal of Clinical Oncology . 2007,第15期

机译：在晚期实体瘤中，丙戊酸随后拓扑异构酶II抑制剂表柔比星抑制组蛋白脱乙酰基酶的I期试验：一项临床和转化研究。
3. Clinical Study: Valproic Acid, a Histone Deacetylase Inhibitor, in Combination with Paclitaxel for Anaplastic Thyroid Cancer: Results of a Multicenter Randomized Controlled Phase II/III Trial [J] . Maria Graziella Catalano, Mariateresa Pugliese, Marco Gallo, International journal of endocrinology . 2016,第Pta2期

机译：临床研究：丙戊酸，一种组蛋白脱乙酰酶抑制剂，与紫杉醇组合用于促进甲状腺癌：多中心随机对照期II / III试验的结果
4. Design of Histone Deacetylase Inhibitors with Chlamydocin Framework containing Various Imino Acids instead of Proline Residue [C] . Izumi Shiraishi, Yasuhiko Ohtsuka, Shokichi Ohuchi International Peptide Symposium . 2009

机译：用含有各种亚氨基酸代替脯氨酸残基的衣原体甲酰胺骨架组蛋白脱乙酰酶抑制剂的设计
5. Chemosensitization of osteosarcoma by the histone deacetylase inhibitor valproic acid. [D] . Wittenburg, Luke A. 2010

机译：组蛋白脱乙酰基酶抑制剂丙戊酸对骨肉瘤的化学增敏作用。
6. DECIDER: prospective randomized multicenter phase II trial of low-dose decitabine (DAC) administered alone or in combination with the histone deacetylase inhibitor valproic acid (VPA) and all-trans retinoic acid (ATRA) in patients 60 years with acute myeloid leukemia who are ineligible for induction chemotherapy [O] . Olga Grishina, Claudia Schmoor, Konstanze Döhner, 2015

机译：决策：低剂量地西他滨（DAC）单独或与组蛋白脱乙酰基酶抑制剂丙戊酸（VPA）和全反式维甲酸（ATRA）联合给药于60岁以上的急性髓细胞性白血病患者的前瞻性随机多中心II期试验没有资格进行诱导化疗
7. DECIDER: prospective randomized multicenter phase II trial of low-dose decitabine (DAC) administered alone or in combination with the histone deacetylase inhibitor valproic acid (VPA) and all- retinoic acid (ATRA) in patients >60 years with acute myeloid leukemia who are ineligible for induction chemotherapy [O] . 2015

机译：决定因素：对于60岁以上的急性髓细胞性白血病患者，单独或与组蛋白脱乙酰酶抑制剂丙戊酸（VPA）和全视黄酸（ATRA）联合使用的低剂量地西他滨（DAC）的前瞻性随机多中心II期临床研究不适合诱导化疗

Clinical and Biological Effects of Valproic Acid as a Histone Deacetylase Inhibitor on Tumor and Surrogate Tissues: Phase I/II Trial of Valproic acid and Epirubicin/FEC

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