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Multifaceted Bioanalytical Methods for the Comprehensive Pharmacokinetic and Catabolic Assessment of MEDI3726, an Anti-Prostate-Specific Membrane Antigen Pyrrolobenzodiazepine Antibody–Drug Conjugate

机译：Medi3726的综合药代动力学和分解代谢评估的多原生物分析方法，一种抗前列腺特异性膜抗原吡咯唑二苯并二氮杂二氮杂苯并二苯并二氮杂氮

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Yue Huang; Christopher J. Del Nagro; Kemal Balic; William R. Mylott; Omnia A. Ismaiel; Eric Ma; Morse Faria; Aaron M. Wheeler; Moucun Yuan; Michael P. Waldron; Marlking G. Peay; Diego F. Cortes; Lorin Roskos; Meina Liang; Anton I. Rosenbaum;
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1. Multifaceted Bioanalytical Methods for the Comprehensive Pharmacokinetic and Catabolic Assessment of MEDI3726, an Anti-Prostate-Specific Membrane Antigen Pyrrolobenzodiazepine Antibody-Drug Conjugate [J] . Huang Yue, Del Nagro Christopher J., Balic Kemal, Analytical chemistry . 2020,第16期

机译：用于MEDI3726的综合药代动力学和分解代谢评估的多原生物分析方法，一种抗前列腺特异性膜抗原吡咯唑二氮杂氮杂苄醇缀合物
2. Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer [J] . Cho Song, Zammarchi Francesca, Williams David G., Molecular cancer therapeutics . 2018,第10期

机译：Medi3726（ADCT-401）的抗肿瘤活性，一种靶向PSMA的吡咯洛二氮杂Zeine抗体 - 药物缀合物，靶向PSMA，前列腺癌的临床前模型
3. Hydrophobic interaction chromatography (HIC) method development and characterization of resolved drug-load variants in site-specifically conjugated pyrrolobenzodiazepine dimer-based antibody drug conjugates (PBD-ADCs) [J] . Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2020,第期

机译：疏水相互作用色谱（HIC）方法的开发和表征分离的药物载体变体在现场 - 特异性缀合的吡咯唑二氮杂氮杂氮杂Zeine二聚体基抗体药物缀合物（PBD-ADC）
4. Addressing Bioanalytical Challenges in Structural Characterization of Next-Generation Antibody-Drug-Conjugates Case Study: Developing a 2nd-Generation Affinity Capture LC-MS to Improve In Vivo Stability Assessment [C] . Dian Su, Carl Ng, Mehraban Khosraviani, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：解决下一代抗体 - 药物 - 缀合物的结构表征中生物分析挑战案例研究：显影第2代亲和力捕获LC-MS以改善体内稳定性评估
5. Investigating the Pharmacokinetics and Pharmacodynamics of Antibody-Drug Conjugates, T Cells and Bispecific Antibodies [D] . Khot, Antari . 2020

机译：调查抗体 - 药物缀合物，T细胞和双特异性抗体的药代动力学和药效学
6. ADME Considerations and Bioanalytical Strategies for Pharmacokinetic Assessments of Antibody-Drug Conjugates [O] . Si Mou, Yue Huang, Anton I. Rosenbaum 2018

机译：抗体-药物结合物的药代动力学评估的ADME注意事项和生物分析策略
7. Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selection [O] . Maribel Beaumont, Daniela Tomazela, Douglas Hodges, 2018

机译：抗体 - 药物缀合物：在铅优化和选择中综合生物分析和生物透明度评估

Multifaceted Bioanalytical Methods for the Comprehensive Pharmacokinetic and Catabolic Assessment of MEDI3726, an Anti-Prostate-Specific Membrane Antigen Pyrrolobenzodiazepine Antibody–Drug Conjugate

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