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Catalytic Dyad Residues His41 and Cys145 Impact the Catalytic Activity and Overall Conformational Fold of the Main SARS-CoV-2 Protease 3-Chymotrypsin-Like Protease

机译：催化DyaD残基HIS41和CYS145影响主要SARS-COV-2蛋白酶3-Chymotrypsin样蛋白酶的催化活性和整体构象折叠

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Juliana C. Ferreira; Samar Fadl; Adrian J. Villanueva; Wael M. Rabeh;
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1. Evidence for Substrate Binding-Induced Zwitterion Formation in the Catalytic Cys-His Dyad of the SARS-CoV Main Protease [J] . Alexander Paasche, Andreas Zipper, Simon Scha?fer, Biochemistry . 2014,第37期

机译：在SARS-CoV主蛋白酶的催化Cys-His Dyad中底物结合诱导的两性离子形成的证据。
2. Conformational flexibility of the catalytic Asp dyad in HIV-1 protease: An ab initio study on the free enzyme. [J] . Piana S, Carloni P Proteins: Structure, Function, and Genetics . 2000,第1期

机译：HIV-1蛋白酶中Asp催化二元构象的柔性：从头开始研究游离酶。
3. Chikungunya nsP2 protease is not a papain-like cysteine protease and the catalytic dyad cysteine is interchangeable with a proximal serine [J] . Chonticha Saisawang, Sawanan Saitornuang, Pornpan Sillapee, Scientific reports. . 2015,第1期

机译：Chikungunya nsP2蛋白酶不是木瓜蛋白酶样半胱氨酸蛋白酶，催化二聚体半胱氨酸可与近端丝氨酸互换
4. Generating Novel Compounds Targeting SARS-CoV-2 Main Protease Based on Imbalanced Dataset [C] . Fan Hu, Dongqi Wang, Yishen Hu, IEEE International Conference on Bioinformatics and Biomedicine . 2020

机译：基于不平衡数据集产生靶向SARS-COV-2主要蛋白酶的新化合物
5. The molecular interactions of the catalytic domain of factor XIa (FXIa): Catalysis of substrates IX and S-2366, inhibition by the Kunitz protease inhibitory domain (KPI) of Protease Nexin 2 (PN2), and binding to the surface of activated platelets. [D] . Miller, Tara N. 2007

机译：因子XIa（FXIa）催化域的分子相互作用：底物IX和S-2366的催化，蛋白酶Nexin 2（PN2）的Kunitz蛋白酶抑制域（KPI）的抑制以及与活化血小板表面的结合。
6. Catalytic Dyad Residues His41 and Cys145 Impact the Catalytic Activity and Overall Conformational Fold of the Main SARS-CoV-2 Protease 3-Chymotrypsin-Like Protease [O] . Juliana C. Ferreira, Samar Fadl, Adrian J. Villanueva, 2021

机译：催化DyaD残基HIS41和CYS145影响主要SARS-COV-2蛋白酶3-Chymotrypsin样蛋白酶的催化活性和整体构象折叠
7. Potential Binding Efficiency of Antiviral Drug Lopinavir Targeted to the Catalytic Dyad, His41 - Cys145 of SARS CoV -2 Main Protease [O] . Muthu Raj S, Manohar M, Mohan M, 2020

机译：抗病毒药物Lopinavir的潜在结合效率，靶向催化Dyad，His41 - COV -2主要蛋白酶的Cys145

Catalytic Dyad Residues His41 and Cys145 Impact the Catalytic Activity and Overall Conformational Fold of the Main SARS-CoV-2 Protease 3-Chymotrypsin-Like Protease

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