Biopharmaceutical Studies of Pharmacopoeial Excipients Based on Pectin and Indicators of Advisability of Their Application in Specific Oral Cavity Environment

摘要

The biopharmaceutical studies have undoubtedly proven that the samples of pharmacopoeial excipients based on polyethylene oxide and sodium carboxymethyl cellulose being heated for 15 minutes lost their viscous consistency and became fluidal functioning as an ointment till the end of the experiment. In contrast, the samples based on apple pectin being heated thickened without hardening slightly accelerating the release of the excipients and functioning as a paste. The experiment data indicated the advisability of using substances based on pectin to develop pharmacopoeial excipients in the form of pastes for application in the specific oral cavity environment.