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Structure of the α-Homo-DNA:RNA Duplex and the Function of Twist and Slide To Catalogue Nucleic Acid Duplexes

机译:α-Homo-DNA的结构:RNA双链体和扭曲和滑动的功能,对目录核酸双链体

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摘要

High-resolution NMR studies of an alpha-homo-DNA:RNA duplex reveal the formation of a right-handed parallel-oriented helix. It differs significantly from a standard A- or B-type helix by a small twist value (26.2 degrees ), which leads to a helical pitch of 13.7 base pairs per helical turn, a negative inclination (-1.78 A) and a large x displacement (5.90 A). The rise (3.4 A) is similar to that found in B-DNA. The solution of this new helix structure has stimulated us to develop a mathematical and geometrical model based on slide and twist parameters to describe nucleic acid duplexes. All existing duplexes can be positioned within this landscape, which can be used to understand the helicalization process.
机译:高分辨率NMR研究α-Homo-DNA:RNA双相揭示了右手平行定向螺旋的形成。它与小捻值(26.2度)的标准A-或B型螺旋显着不同,这导致每个螺旋转弯的螺旋间距为13.7个碱基对,负倾斜度(-1.78a)和大x位移(5.90 a)。崛起(3.4a)类似于B-DNA中发现的类似。这种新的螺旋结构的解决方案刺激了我们基于滑动和扭曲参数来描述核酸双链体的数学和几何模型。所有现有的双工都可以定位在这种景观中,可用于了解幽灵化过程。

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