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Process and Formulation Effects on Protein Structure in Lyophilized Solids Using Mass Spectrometric Methods

机译：使用质谱法测定冻干固体中蛋白质结构的方法和配方效应

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Lavanya K. Iyer; Gregory A. Sacha; Balakrishnan S. Moorthy; Steven L. Nail; Elizabeth M. Topp;
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1. Predicting protein aggregation during storage in lyophilized solids using solid state amide hydrogen/deuterium exchange with mass spectrometric analysis (ssHDX-MS) [J] . MoorthyB.S., SchultzS.G., KimS.G., Molecular pharmaceutics . 2014,第6期

机译：使用固态酰胺氢/氘交换和质谱分析（ssHDX-MS）预测冻干固体中存储期间的蛋白质聚集
2. Optimizing the Formulation and Lyophilization Process for a Fragment Antigen Binding (Fab) Protein Using Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry (ssHDX-MS) [J] . Kumar Lokesh, Chandrababu Karthik Balakrishna, Balakrishnan Shenbaga Moorthy, Molecular pharmaceutics . 2019,第11期

机译：使用固态氢 - 氘交换质谱法（SSHDX-MS）优化片段抗原结合（Fab）蛋白的配方和冻干方法
3. Storage stability of keratinocyte growth factor-2 in lyophilized formulations: Effects of formulation physical properties and protein fraction at the solid-air interface [J] . DevineniD., GonschorekC., CiceroneM.T., European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2014,第2期

机译：冻干制剂中角质形成细胞生长因子2的储存稳定性：固-气界面制剂物理性质和蛋白质组分的影响
4. Mass Spectrometric Method to Determine pKa Values of Individual Histidine Residues in Proteins [C] . Masaru Miyagi, Takashi Nakazawa ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：质谱法测定蛋白质中单个组氨酸残基的PKA值
5. Characterization of protein structure in the solid state by H/D exchange with mass spectrometry and its application in lyophilized protein formulation [D] . Li, Yunsong 2007

机译：通过质谱进行H / D交换表征固态蛋白质结构及其在冻干蛋白质制剂中的应用
6. Process and Formulation Effects on Protein Structure in Lyophilized Solids using Mass Spectrometric Methods [O] . Lavanya K. Iyer, Gregory A. Sacha, Balakrishnan S. Moorthy, -1

机译：质谱方法对冻干固体中蛋白质结构的加工和配方影响
7. Storage stability of keratinocyte growth factor-2 in lyophilized formulations: Effects of formulation physical properties and protein fraction at the solid–air interface [O] . Dilip Devineni, Christoph Gonschorek, Marcus T. Cicerone, 2014

机译：冻干制剂中角质形成细胞生长因子-2的储存稳定性：制剂物理性质和蛋白质馏分在固体空中界面的影响

Process and Formulation Effects on Protein Structure in Lyophilized Solids Using Mass Spectrometric Methods

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