首页> 外文OA文献 >Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities

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Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities

机译：C6苄基和C6甲基甲基取代的2-羟基异喹啉-1,3-型抗体的设计，合成，生物化学和抗病毒评价：对HIV逆转录酶相关的RNase H和具有抗病毒活性的聚合酶的双重抑制作用

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Sanjeev Kumar V. Vernekar; Zheng Liu; Eva Nagy; Lena Miller; Karen A. Kirby; Daniel J. Wilson; Jayakanth Kankanala; Stefan G. Sarafianos; Michael A. Parniak; Zhengqiang Wang;
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1. Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities [J] . Vernekar Sanjeev Kumar V., Liu Zheng, Nagy Eva, Journal of Medicinal Chemistry . 2015,第2期

机译：设计，合成，生化和抗病毒评价的C 6苄基和C 6联芳甲基取代的2-羟基异喹啉-1，3-二酮：对HIV逆转录酶相关的RNase H和聚合酶具有抗病毒活性的双重抑制
2. Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases [J] . Esposito Francesca, Kharlamova Tatyana, Distinto Simona, The FEBS journal . 2011,第9期

机译：茜素衍生物作为HIV-1逆转录酶相关DNA聚合酶和RNase H活性的新型双重抑制剂，对非核苷抗性逆转录酶的RNase H活性也有效
3. 6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity [J] . Lei Wang, Jing Tang, Andrew D. Huber, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2018,第期

机译：6-芳硫基-3-羟基吡啶氨酸-2,4-致力于抗病毒活性抑制HIV逆转录酶相关的RNA酶H.
4. Design Synthesis Biochemical and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-13-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities [O] . Sanjeev Kumar V. Vernekar, Zheng Liu, ∥, -1

机译：设计合成生化和抗病毒C6苄基和C6联芳甲基取代的2-羟基异喹啉-13-二酮的评估：对HIV逆转录酶相关的RNase H和聚合酶具有抗病毒活性的双重抑制
5. Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases [O] . Esposito F, Kharlamova T, Distinto S, 2011

机译：茜素衍生物作为HIV-1逆转录酶相关DNA聚合酶和RNase H活性的新型双重抑制剂，对非核苷抗性逆转录酶的RNase H活性也有效

Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities

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