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A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells

机译：IL-2异二聚体受体的双特异性抗体激动剂优先促进CD8和NK细胞的体内膨胀

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Katherine E. Harris; Kyle J. Lorentsen; Harbani K. Malik-Chaudhry; Kaitlyn Loughlin; Harish Medlari Basappa; Sharon Hartstein; Ghenima Ahmil; Nicole S. Allen; Brian C. Avanzino; Aarti Balasubramani; Andrew A. Boudreau; Karen Chang; Maria-Cristina Cuturi; Laura M. Davison; Dennis M. Ho; Suhasini Iyer; Udaya S. Rangaswamy; Preethi Sankaran; Ute Schellenberger; Roland Buelow; Nathan D. Trinklein;
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1. 451?Combining Bempegaldesleukin (CD122-preferential IL-2 pathway agonist) and NKTR-262 (TLR7/8 agonist) pairs local innate activation with systemic CD8 T cell expansion to enhance anti-tumor immunity [J] . Annah Rolig, Daniel Rose, Saul Kivimae, Journal for ImmunoTherapy of Cancer . 2020,第Suppla3期

机译：451？组合Bempegaldesleukin（CD122-优先IL-2途径激动剂）和NKTR-262（TLR7 / 8激动剂）对全系统CD8 T细胞扩张的本地先天激活，增强抗肿瘤免疫力
2. Activation and preferential expansion of rat cytotoxic (CD8) T cells in vitro and in vivo with a bispecific (anti-TCR alpha/beta x anti-CD2) F(ab')2 antibody. [J] . Tutt AL, Reid R, Wilkins BS, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1995,第6期

机译：用双特异性（抗TCRα/βx抗CD2）F（ab'）2抗体在体外和体内活化和优先扩增大鼠细胞毒性（CD8）T细胞。
3. Activation and preferential expansion of rat cytotoxic (CD8) T cells in vitro and in vivo with a bispecific (anti-TCR alpha/beta x anti-CD2) F(ab')2 antibody. [J] . A L Tutt, R Reid, B S Wilkins, The journal of immunology . 1995,第6期

机译：用双特异性（抗TCRα/βx抗CD2）F（ab'）2抗体在体外和体内激活和优先扩增大鼠细胞毒性（CD8）T细胞。
4. A Bispecific Antibody Based on Heterodimeric Fc Demonstrates Potent Anti-Tumor Efficacy by Targeting Met and VEGFR-2 Simultaneously [C] . Ye-Jin Kim, Hye-Ji Choi, Yong-Sung Kim PEGS . 2014

机译：基于异二聚体Fc的双特异性抗体通过同时靶向满足和VEGFR-2来证明有效的抗肿瘤效果
5. Development of a novel antibody molecule for redirected T cell immunity to tumor cells: The bispecific single chain antibody [D] . Gruber, Meegan Minori 1996

机译：用于重定向T细胞对肿瘤细胞免疫的新型抗体分子的开发：双特异性单链抗体
6. Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death [O] . Laurence E. Cheng, Claes Öhlén, Brad H. Nelson, 2002

机译：通过抗原识别调节的CD8 + T细胞中IL-2受体的增强信号转导导致应答性CD8 + T细胞优先增殖和扩展而不是促进细胞死亡
7. Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death [O] . Cheng, Laurence E., Öhlén, Claes, Nelson, Brad H., 2002

机译：通过抗原识别调节的CD8 + T细胞中IL-2受体的增强信号转导导致应答性CD8 + T细胞优先增殖和扩展，而不是促进细胞死亡

A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells

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