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Tissue-type Plasminogen Activator (tPA) Interacts with Urokinase-type Plasminogen Activator (uPA) via tPA's Lysine Binding Site

机译：组织型纤溶酶原激活剂（TPA）通过TPA的赖氨酸结合位点与尿激酶型纤溶酶原激活剂（UPA）相互作用

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Valery Novokhatny; Leonid Medved; H. Roger Lijnen; Kenneth Ingham;
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年度 1995
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1. Introduction of an RRHR motif into chicken urokinase-type plasminogen activator (ch-uPA) confers sensitivity to plasminogen activator inhibitor (PAI)-1 and PAI-2 and allows ch-uPA-mediated extracellular matrix degradation to be controlled by PAI-1 [J] . John D. Sipley, Daniela S. Alexander, Jacqueline E. Testa Proceedings of the National Academy of Sciences of the United States of America . 1997,第7期

机译：在鸡尿激酶型纤溶酶原激活物（ch-uPA）中引入RRHR基序可赋予对纤溶酶原激活物抑制剂（PAI）-1和PAI-2的敏感性，并使ch-uPA介导的细胞外基质降解受PAI-1控制
2. INTRODUCTION OF AN RRHR MOTIF INTO CHICKEN UROKINASE-TYPE PLASMINOGEN ACTIVATOR (CH-UPA) CONFERS SENSITIVITY TO PLASMINOGEN ACTIVATOR INHIBITOR (PAP)-1 AND PAI-2 AND ALLOWS CH-UPA-MEDIATED EXTRACELLULAR MATRIX DEGRADATION TO BE CONTROLLED BY PAI-1 [J] . Sipley JD., Testa JE., Quigley JP., Proceedings of the National Academy of Sciences of the United States of America . 1997,第7期

机译：向鸡尿激酶型纤溶酶原激活物（CH-UPA）中引入RRHR母题可赋予纤溶酶原激活物抑制剂（PAP）-1和PAI-2敏感性，并允许通过CH-UPA介导的细胞外基质降解1
3. Thrombomodulin levels during normal pregnancy, at delivery and in the postpartum: comparison with tissue-type plasminogen activator and plasminogen activator inhibitor-1. [J] . de-Moerloose P, Mermillod N, Amiral J, Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and Haemostasis . 1998,第3期

机译：正常妊娠期间，分娩时和产后的血栓调节素水平：与组织型纤溶酶原激活物和纤溶酶原激活物抑制剂-1的比较。
4. Laser thrombolysis and in vitro study of Tissue Plasminogen Activators (tPA) Release Encapsulated by Chitosan Coated PLGA Nanoparticles for acute myocardial infarction (AMI) [C] . Mahboobeh Mahmoodi, Mohammad E. Khosroshahi, Fatemeh Atyabi Proceedings of the world medical conference . 2010

机译：激光溶栓和壳聚糖涂层PLGA纳米颗粒包裹的组织纤溶酶原激活剂（tPA）释放的体外研究用于急性心肌梗死（AMI）
5. A structure-function analysis of the lysine-binding kringle 2 domains of human tissue-type plasminogen activator and human plasminogen by strategic mutagenesis. [D] . Nilsen, Stephanie Lynn. 1999

机译：通过战略诱变对人体组织型纤溶酶原激活物和纤溶酶原的赖氨酸结合kringle 2域的结构功能分析。
6. Interaction between plasminogen activator inhibitor type 1 (PAI-1) bound to fibrin and either tissue-type plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA). Binding of t-PA/PAI-1 complexes to fibrin mediated by both the finger and the kringle-2 domain of t-PA. [O] . O F Wagner, C de Vries, C Hohmann, 1989

机译：与纤维蛋白结合的1型纤溶酶原激活物抑制剂（PAI-1）与组织型纤溶酶原激活物（t-PA）或尿激酶型纤溶酶原激活物（u-PA）之间的相互作用。 t-PA / PAI-1复合物与t-PA的手指和kringle-2结构域介导的纤维蛋白结合。
7. Interaction between plasminogen activator inhibitor type 1 (PAI-1) bound to fibrin and either tissue-type plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA). Binding of t-PA/PAI-1 complexes to fibrin mediated by both the finger and the kringle-2 domain of t-PA. [O] . Wagner, O F, de Vries, C, Hohmann, C, 1989

机译：与纤维蛋白结合的1型纤溶酶原激活物抑制剂（PAI-1）与组织型纤溶酶原激活物（t-PA）或尿激酶型纤溶酶原激活物（u-PA）之间的相互作用。 t-PA / PAI-1复合物与t-PA的手指和kringle-2结构域介导的纤维蛋白结合。
8. Tissue Plasminogen Activator (tPA) Mediates Neurotoxin-Induced Cell Death and Microglial Activation. [R] . Tsirka, S. E. 2001

机译：组织纤溶酶原激活物（tpa）介导神经毒素诱导的细胞死亡和小胶质细胞激活。

Tissue-type Plasminogen Activator (tPA) Interacts with Urokinase-type Plasminogen Activator (uPA) via tPA's Lysine Binding Site

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