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A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea – dose optimization, clinical outcomes, and CD4+ T cell responses

机译：一种新的人体挑战模型，用于测试肠毒素大肠杆菌腹泻剂量优化，临床结果和CD4 + T细胞反应的肠毒素基毒素候选患者

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Sunniva Todnem Sakkestad; Hans Steinsland; Steinar Skrede; Kristine Lillebø; Dag Harald Skutlaberg; Anne Berit Guttormsen; Anton Zavialov; Sari Paavilainen; Hanne Søyland; Marianne Sævik; Astrid Rykkje Heien; Marit Gjerde Tellevik; Eileen Barry; Nina Langeland; Halvor Sommerfelt; Kurt Hanevik;
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1. A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea dose optimization, clinical outcomes, and CD4+ T cell responses [J] . Sunniva Todnem Sakkestad, Hans Steinsland, Steinar Skrede, PLOS Neglected Tropical Diseases . 2019,第10期

机译：一种新的人类挑战模型，用于测试基于热稳定毒素的疫苗候选物的产肠毒素性大肠杆菌腹泻剂量优化，临床结果和CD4 + T细胞反应
2. Impact of CD4+ T Cell Responses on Clinical Outcome following Oral Administration of Wild-Type Enterotoxigenic Escherichia coli in Humans [J] . Monica A. McArthur, Wilbur H. Chen, Laurence Magder, PLOS Neglected Tropical Diseases . 2017,第1期

机译：口服人类野生型肠毒素大肠杆菌后CD4 + T细胞反应对临床结果的影响
3. Impact of lower challenge doses of enterotoxigenic Escherichia coli on clinical outcome, intestinal colonization and immune responses in adult volunteers [J] . Subhra Chakraborty, Clayton Harro, Barbara DeNearing, PLOS Neglected Tropical Diseases . 2018,第4期

机译：较低剂量的产肠毒素大肠杆菌对成人志愿者的临床结局，肠道定植和免疫反应的影响
4. Nanoparticulated Heat-Stable(STa)and Heat-Labile B Subunit(LTB)Recombinant Toxin Improves Vaccine Protection Against Enterotoxigenic Escherichia coli Challenge in Mouse [C] . Deng Guangcun, Zeng Jin, Jian Minjie, 16th International congress on animal hygiene : animal hygiene, health and welfare as corner stones of sustainable animal production . 2013

机译：纳米颗粒热稳定（STa）和不耐热B亚基（LTB）重组毒素可提高疫苗抵抗小鼠肠毒素性大肠杆菌的挑战
5. Enterotoxigenic Escherichia coli promotes its adherence to intestinal epithelial cells through heat-labile enterotoxin-dependent and independent mechanisms. [D] . Johnson, Amber M. 2008

机译：产肠毒素的大肠杆菌通过不耐热的肠毒素依赖性和非依赖性机制来促进其对肠上皮细胞的粘附。
6. A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea – dose optimization clinical outcomes and CD4+ T cell responses [O] . Sunniva Todnem Sakkestad, Hans Steinsland, Steinar Skrede, 2019

机译：一种新的人类挑战模型用于测试热稳定的基于毒素的候选疫苗来治疗产肠毒素的大肠杆菌性腹泻–剂量优化临床结果和CD4 + T细胞反应
7. Impact of CD4+ T Cell Responses on Clinical Outcome following Oral Administration of Wild-Type Enterotoxigenic Escherichia coli in Humans. [O] . Monica A McArthur, Wilbur H Chen, Laurence Magder, 2017

机译：CD4 + T细胞应答对人类口服野生型肠毒素大肠杆菌后临床结果的影响。
8. Volunteer Challenge With Enterotoxigenic Escherichia coli That Express Intestinal Colonization Factor Fimbriae CS17 and CS19 [R] . McKenzie, R., Porter, C. K., Cantrell, J. A., 2011

机译：产肠毒素大肠杆菌的志愿者挑战，表达肠道定植因子Fimbriae Cs17和Cs19

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A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea – dose optimization, clinical outcomes, and CD4+ T cell responses

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