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TAK-063, a Novel Phosphodiesterase 10A Inhibitor, Protects from Striatal Neurodegeneration and Ameliorates Behavioral Deficits in the R6/2 Mouse Model of Huntington’s Disease

机译：TAK-063，一种新型磷酸二酯酶10A抑制剂，免受纹状体神经变性的保护，并在亨廷顿疾病的R6 / 2小鼠模型中改善行为缺陷

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Akina Harada; Kazunori Suzuki; Haruhide Kimura;
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1. TAK-063, a Novel Phosphodiesterase 10A Inhibitor, Protects from Striatal Neurodegeneration and Ameliorates Behavioral Deficits in the R6/2 Mouse Model of Huntington's Diseases [J] . Harada Akina, Suzuki Kazunori, Kimura Haruhide The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2017,第1期

机译：TAK-063，一种新型磷酸二酯酶10A抑制剂，免受纹状体神经变性的保护，并改善亨廷顿疾病R6 / 2小鼠模型中的行为缺陷
2. Phosphodiesterase type IV inhibition prevents sequestration of CREB binding protein, protects striatal parvalbumin interneurons and rescues motor deficits in the R6/2 mouse model of Huntington's disease. [J] . Giampa C, Middei S, Patassini S, The European Journal of Neuroscience . 2009,第5期

机译：IV型磷酸二酯酶抑制作用可防止CREB结合蛋白被隔离，保护纹状体小白蛋白中间神经元并挽救亨廷顿氏病R6 / 2小鼠模型的运动功能障碍。
3. N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's disease [J] . D J Wright, T Renoir, Z M Smith, Translational psychiatry. . 2015,第1期

机译：n - 乙酰琥珀酸盐改善了线粒体功能，并改善了亨廷顿疾病R6 / 1小鼠模型中的行为缺陷
4. Cerium Oxide Nanoparticles Protect Against MPTP-Induced Dopaminergic Neurodegeneration In A Mouse Model For Parkinson's Disease [C] . Dillon CE, Billings M, Hockey KS, NSTI nanotechnology conference and expo;Nanotech conference expo;NSTI-Nanotech 2011;TechConnect world annual conference expo . 2011

机译：氧化铈纳米颗粒可预防MPTP诱发的帕金森氏病小鼠模型中的多巴胺能神经变性
5. The Role of Trophic Factors and Other Drugs in the Treatment of Huntington's Disease in R6/2 Mouse Model. [D] . Ciesler, Jessica. 2013

机译：营养因子和其他药物在R6 / 2小鼠模型中治疗亨廷顿舞蹈病中的作用。
6. Conditioned medium from amniotic cells protects striatal degeneration and ameliorates motor deficits in the R6/2 mouse model of Huntingtons disease [O] . Carmela Giampà, Alessandra Alvino, Marta Magatti, 2019

机译：来自羊水细胞的条件培养基可保护亨廷顿氏病R6 / 2小鼠模型中的纹状体变性并改善运动功能障碍
7. Conditioned medium from amniotic cells protects striatal degeneration and ameliorates motor deficits in the R6/2 mouse model of Huntington's disease [O] . Carmela Giampà, Alessandra Alvino, Marta Magatti, 2018

机译：来自羊膜细胞的条件培养基保护脊椎肠道疾病R6 / 2小鼠模型中的纹状体变性和改善电机缺陷

TAK-063, a Novel Phosphodiesterase 10A Inhibitor, Protects from Striatal Neurodegeneration and Ameliorates Behavioral Deficits in the R6/2 Mouse Model of Huntington’s Disease

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