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An apportionment method for the oxidative potential of atmospheric particulate matter sources: application to a one-year study in Chamonix, France

机译:大气颗粒物质氧化潜力的分配方法:在法国夏蒙尼的一年度研究中的应用

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摘要

Inhaled aerosolized particulate matter (PM) induces cellular oxidative stress invivo, leading to adverse health outcomes. The oxidative potential (OP) of PMappears to be a more relevant proxy of the health impact of the aerosol ratherthan the total mass concentration. However, the relative contributions of theaerosol sources to the OP are still poorly known. In order to better quantifythe impact of different PM sources, we sampled aerosols in a French city for oneyear (2014, 115 samples). A coupled analysis with detailed chemicalspeciation (more than 100 species, including organic and carbonaceous compounds,ions, metals and aethalometer measurements) and two OP assays (ascorbic acid, AA, and dithiothreitiol, DTT) in a simulated lung fluid (SLF) were performedin these samples. We present in this study a statistical framework using acoupled approach with positive matrix factorization (PMF) and multiple linearregression to attribute a redox-activity to PM sources. Our results highlightthe importance of the biomass burning and vehicular sources to explain theobserved OP for both assays. In general, we see a different contribution of thesources when considering the OP AA, OP DTT or the mass of thePM10. Moreover, significant differences are observed betweenthe DTT and AA tests which emphasized chemical specificities of the two testsand the need of a standardized approach for the future studies onepidemiology or toxicology of the PM.
机译:吸入雾化颗粒物质(PM)诱导细胞氧化应激体内,导致不良健康结果。 PM的氧化潜力(OP)似乎是气溶胶的健康影响的更相关的代理比总质量浓度。但是,相对贡献op的气溶胶源仍然众所周知。为了更好地量化不同PM来源的影响,我们在法国城市进行了采样的气溶胶年(2014年,115个样本)。具有详细化学品的耦合分析形态(100多种物种,包括有机和碳质化合物,进行离子,金属和聚体测量测量)和模拟肺液(SLF)中的两种OP测定(抗坏血酸,AA和二噻唑钛酸DTT)在这些样品中。我们在这项研究中展示了一个使用a的统计框架具有正矩阵分解(PMF)和多个线性的耦合方法回归将氧化还原活动归因于PM源。我们的结果亮点生物质燃烧和车辆来源的重要性来解释观察到两个测定的OP。一般来说,我们看到了不同的贡献在考虑OP AA,OP DTT或质量时,来源PM10。此外,观察到之间的显着差异强调两次测试的化学特异性的DTT和AA测试还需要对未来研究的标准化方法PM的流行病学或毒理学。

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