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IMPORTANCE trial: a provisional study-design of a single-center, phase II, double-blinded, placebo-controlled, randomized, 4-week study to compare the efficacy and safety of intranasal esketamine in chronic opioid refractory pain

机译：重要性试验：临时研究 - 单中心，II期，双盲，安慰剂控制，随机的4周的研究，以比较鼻内eskamine在慢性阿片类药物耐火疼痛中的疗效和安全性

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Mauricio Fernandes; Magdalena Schelotto; Philipp Maximilian Doldi; Giovanna Milani; Abul Andrés Ariza Manzano; Doriam Perera Valdivia; Alexandra Marie Winter Matos; Yasmin Hamdy Abdelrahim; Shaza Ahmed Hamad Bek; Benito K. Benitez; Vanessa Luiza Romanelli Tavares; Abdulrahim M. Basendwah; Luis Henrique Albuquerque Sousa; Naiara Faria Xavier; Tania Zertuche Maldonado; Sarah Toyomi de Oliveira; Melisa Chaker; Michelle Menon Miyake; Elif Uygur Kucukseymen; Kinza Waqar; Ola M.J. Alkhozondar; Ricardo Bernardo da Silva; Guilhermo Droppelmann; Antonio Vaz de Macedo; Rui Nakamura; Felipe Fregni;
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IMPORTANCE trial: a provisional study-design of a single-center, phase II, double-blinded, placebo-controlled, randomized, 4-week study to compare the efficacy and safety of intranasal esketamine in chronic opioid refractory pain

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