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An Adaptive Physiologically Based Pharmacokinetic–Driven Design to Investigate the Effect of Itraconazole and Rifampicin on the Pharmacokinetics of Molibresib (GSK525762) in Healthy Female Volunteers

机译：一种适应性的生理学的药代动力学驱动设计，以研究伊唑康唑和利福平对健康女性志愿者摩拉（GSK525762）的药代动力学的影响

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Kylie Riddell; Aarti Patel; Gary Collins; Yanyan Zhou; Dan Schramek; Brandon E. Kremer; Geraldine Ferron‐Brady;
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1. Pharmacokinetic and pharmacodynamic interaction of nadolol with itraconazole, rifampicin and grapefruit juice in healthy volunteers [J] . MisakaS., MiyazakiN., YatabeM.S., The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2013,第7期

机译：纳多洛尔与伊曲康唑，利福平和葡萄柚汁在健康志愿者中的药代动力学和药效学相互作用
2. Simultaneously predict pharmacokinetic interaction of rifampicin with oral versus intravenous substrates of cytochrome P450 3A/P-glycoprotein to healthy human using a semi-physiologically based pharmacokinetic model involving both enzyme and transporter turnover [J] . Qian Chao-qun, Zhao Kai-jing, Chen Yang, European journal of pharmaceutical sciences . 2019,第期

机译：使用涉及酶和运输工具周转压的半生理学的药代动力学模型，同时预测利福平与口服静脉内底物与口服静脉内底物与健康人的药代动力学相互作用
3. Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug-Drug-Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole [J] . Tuerk Denise, Hanke Nina, Wolf Sarah, Clinical pharmacokinetics . 2019,第12期

机译：用于预测复合CYP2C8和OATP1B1（SLCO1B1）药物 - 药物 - 基因相互作用的生理学基础药代动力学模型：Gemfibrozil，Repaglinide，Pioglitazone，利福平，克拉霉素和伊唑唑啉代株的建模网络
4. Single-Dose Pharmacokinetics of Bioadhesive Itraconazole Tablets (Spherazole) in Healthy Volunteers [C] . Jules Jacob, Michael Bassett, Rebecca Doane, Annual meeting exposition of the Controlled Release Society . 2005

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6. Recommendations for the Design of Clinical Drug–Drug Interaction Studies With Itraconazole Using a Mechanistic Physiologically‐Based Pharmacokinetic Model [O] . Yuan Chen, Tamara D. Cabalu, Ernesto Callegari, 2019

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An Adaptive Physiologically Based Pharmacokinetic–Driven Design to Investigate the Effect of Itraconazole and Rifampicin on the Pharmacokinetics of Molibresib (GSK525762) in Healthy Female Volunteers

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