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Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy

机译：有效的2,4-二氟 - 接头聚（ADP-核糖）聚合酶1抑制剂，具有增强的水溶性和体内抗癌疗效

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Wen-hua Chen; Shan-shan Song; Ming-hui Qi; Xia-juan Huan; Ying-qing Wang; Hualiang Jiang; Jian Ding; Guo-bin Ren; Ze-hong Miao; Jian Li;
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1. Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy [J] . Wen-hua CHEN, Jian LI, Shan-shan SONG, 中国药理学报：英文版 . 2017,第011期

机译：发现具有增强的水溶性和体内抗癌功效的有效的2,4-二氟连接基聚（ADP-核糖）聚合酶1抑制剂
2. Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1/2 Inhibitor, as an Anticancer Agent [J] . Wang Bing, Chu Daniel, Feng Ying, Journal of Medicinal Chemistry . 2016,第1期

机译：（8S，9R）-5-氟-8-（4-氟苯基）-9-（1-甲基-1H-1,2,4-三唑-5-基）-2,7,8的发现和表征9-tetrahydro-3H-吡啶并[4,3,2-de] phthalazin-3-one（BMN 673，Talazoparib），一种新型，高强度，口服有效的聚（ADP-核糖）聚合酶-1/2抑制剂，作为抗癌药
3. Beneficial effects of 5-aminoisoquinolinone, a novel, potent, water-soluble, inhibitor of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occlusion and reperfusion. [J] . Di Paola R, Genovese T, Caputi AP, European Journal of Pharmacology: An International Journal . 2004,第2a3期

机译：5-氨基异喹啉酮（一种新型有效的水溶性聚（ADP-核糖）聚合酶抑制剂）在内脏动脉闭塞和再灌注的大鼠模型中的有益作用。
4. Design, Synthesis, and Cytoprotective Effect of 2-Aminothiazole Analogues as Potent Poly(ADP-Ribose) Polymerase-1 Inhibitors [C] . Wen-Ting Zhang, Gang-Ying Chen, Yi-Jing Zhu, ICMSI;International conference of molecular simulations and applied informatics technologies . 2010

机译：2-氨基噻唑类似物作为强力聚（ADP-核糖）聚合酶-1抑制剂的设计，合成和细胞保护作用
5. Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity [D] . Velagapudi, Uday Kiran. 2019

机译：聚（ADP-核糖）聚合酶抑制剂的设计与合成：腺苷袋结合基序附录对3-氧代-2,3-二氢苯并呋喃-7-甲酰胺对效力和选择性的影响
6. Discovery of potent 24-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy [O] . Wen-hua Chen, Shan-shan Song, Ming-hui Qi, 2017

机译：发现具有增强的水溶性和体内抗癌功效的有效的24-二氟连接基聚（ADP-核糖）聚合酶1抑制剂
7. Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock [O] . McDonald, M C, Mota-Filipe, H, Wright, J A, 2000

机译：水溶性强力抑制剂5-氨基异喹啉酮对聚（ADP-核糖）聚合酶活性的影响对失血性休克引起的器官损伤和功能障碍的影响
8. Mechanisms of Poly(ADP-ribose) polymerase Catalysis; Mono-ADP-ribosylation of Poly(ADP-ribose) polymerase at Nanomolar Concentrations of NAD [R] . Bauer, P. I., Hakam, A., Kun, E. 1986

机译：聚（aDp-核糖）聚合酶催化机制;纳摩尔浓度的NaD的聚（aDp-核糖）聚合酶的单-aDp-核糖基化

Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy

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