Abstract Medical images are blurred and noised due to various reasons in the acquirement, transmission and storage. In order to improve the restoration quality of medical images, a regular super-resolution restoration algorithm based on fuzzy similarity fusion is proposed. Based on maintained similarity in multiple scales, the fused similarity of the medical images is computed by fuzzy similarity fusion. First, fuzzy similarity is determined by the regional features. The images with certain similarity are obtained according to the maximum value, and the fused image is obtained by all obvious regional features. Then, an adaptive regularized restoration algorithm is employed. In order to ensure the objective function has a global optimal solution, regularized parameters of the global minimum solution of nonlinear function are solved iteratively. Finally, experimental results show that mean square error (MSE) and peak signal-to-noise ratio (PSNR) of the restored image are visibly improved. The restored image also has an obvious improvement in the burr of local edge. Moreover, the algorithm has good stability with significantly enhanced PSNR.
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